L8515-500UG - CONOTOXIN IMI (alpha-)
(Syn. : alpha-CTx ImI)
(Syn. : alpha-CTx ImI)
CONOTOXIN IMI (alpha-) | Product ID | L8515-500UG |
| Name | CONOTOXIN IMI (alpha-) |
| Molecular formula | C52H78N20O15S4 |
| Description |
A 12 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Imperial cone snail Conus imperialis. |
| Biological activity | α-conotoxin IMI blocks neuronal alpha-3/beta-2 (human and rat), alpha-7 (human and rat), and alpha-3/beta-4 (human) nAChRs. Acts voltage-independently. Competes with alpha-bungarotoxin for binding to the receptor. Binds to a different site than alpha-conotoxin IMII. Is highly active against the neuromuscular receptor in frog. It does not inhibit alpha-2-beta-2, alpha-4-beta-2, alpha-2-beta-4, alpha-3-beta-4, and alpha-4-beta-4 subunits. Has also no effect on muscle nAChRs alpha-1-beta-1-delta-epsilon. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 90.00 | ||
| 5 Unité(s) | 360.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8515-500UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8515-500UG | Molecular weight | 1352.92 Da |
| Product name | CONOTOXIN IMI (alpha-) | Physical form | White lyophilized solid |
| CAS No. | 156467-85-5 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P50983 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 133011 | ||
| Purity | > 98 % (HPLC) | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8515-500UG |
| Product name | CONOTOXIN IMI (alpha-) |
- 1. Ellison, M., et al. (2003) Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites, J Biol Chem. ;
2. Johnson, D. S., et al. (1995) Alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors, Mol Pharmacol.  ;
3. McIntosh, J. M., et al. (1994) A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI, J Biol Chem. ;
4. Rogers, J. P., et al. (2000) Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist, J Mol Biol.
Links
| Product code | L8515-500UG |
| Product name | CONOTOXIN IMI (alpha-) |
| External Links |
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