L8521-100UG - CONOTOXIN SO3 (omega-)
CONOTOXIN SO3 (omega-) | Product ID | L8521-100UG |
| Name | CONOTOXIN SO3 (omega-) |
| Molecular formula | C100H166N36O31S6 |
| Description |
A 25 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Striated cone snail Conus striatus. |
| Biological activity | ω-conotoxin SO3 acts at presynaptic membranes, it binds and blocks voltage-gated calcium channels (Cav). This peptide selectively targets Cav2.2/CACNA1B (IC50=160 nM) voltage-gated calcium channels. When tested in mammals, this toxin displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects (tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion) compared with identical dosages of MVIIA injected intrathecally. It has no effect on R-type calcium currents, voltage-gated sodium currents, delayed rectifier potassium currents and transient outward potassium currents. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 190.00 | ||
| 5 Unité(s) | 760.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8521-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8521-100UG | Molecular weight | 2561.00 Da |
| Product name | CONOTOXIN SO3 (omega-) | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | Q9XZK2 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8521-100UG |
| Product name | CONOTOXIN SO3 (omega-) |
- 1. Li, Z., et al. (2003) Effect of new O-superfamily conotoxin SO3 on sodium and potassium currents of cultured hippocampal neurons, Brain Res. ;
2. Wen, L., et al. (2005) SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons, Br J Pharmacol.
Links
| Product code | L8521-100UG |
| Product name | CONOTOXIN SO3 (omega-) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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