L8102-1MG - CARDIOTOXIN
(Syn. : CTX-1, Cytotoxin 1, Cardiotoxin gamma)
(Syn. : CTX-1, Cytotoxin 1, Cardiotoxin gamma)
CARDIOTOXIN | Product ID | L8102-1MG |
| Name | CARDIOTOXIN |
| Molecular formula | |
| Description |
It is a protein kinase C specific inhibitor with an IC50 of 1-3 μM. It depolarizes cardiomyocytes. It has also lytic activity on other cells like red blood cells. 60-amino acid peptide with 4 disulfide bridges , from Naja pallida snake venom. |
| Biological activity | It interacts with sulfatides in the cell membrane. This induces pore formation and cell internalization responsible for cytotoxicity in cardiomyocytes. It has also an action on mitochondrial mambrane which leads to swelling and fragmentation. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 178.00 | ||
| 5 Unité(s) | 712.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8102-1MG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8102-1MG | Molecular weight | 6,800 Da |
| Product name | CARDIOTOXIN | Physical form | |
| CAS No. | 56574-47-1 | Melting point | |
| RTECS | Solubility | Well in water and saline | |
| UNIPROT | P01468 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | |||
| Purity | > 99 % (HPLC) | ||
| Toxicity(LD50) | IVN-MUS LD100: 1.5-1.7 mg/kg | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable in freeze-dried state |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L8102-1MG |
| Product name | CARDIOTOXIN |
- Chiou et al., "Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and mode of enzyme inhibition." Biochemistry 1993 32(8):2062-2067
- Fletcher et al., "Possible mechanisms of Action of cobra snake venom cardiotoxins and bee venom melittin." Toxicon 1993 31(6):669-695
- Raynor et al., "Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin." J. Biol. Chem. 1991 266(5): 2753-2758
- D'Albis et al., "Regeneration after cardiotoxin injury of innervated and denervated slow and fast muscles of mammals." Eur. J. Biochem. 1988 174:103-110
- Grognet et al., Molecular Immunology 1986 23(12):1329-1337
- Fryklund et al., Biochemistry 1975 14:2865
Links
| Product code | L8102-1MG |
| Product name | CARDIOTOXIN |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
