CLOFLUBICYNE
Product ID L9001-1MG 
Name CLOFLUBICYNE 
Molecular formula C11H6F6N2Cl2
Description

This is a potent non-competitive GABA antagonist, a convulsant and a laboratory insecticide.


Organofluorate compound , synthetic
Biological activity

The IC50 for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 10 nM. The inhibition of the GABA-dependent Cl- current occurs at 5.3 nM.

Experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Flunitrazepam) showed no influence of Cloflubicyne up to 10 μM.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 1mg 110.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L9001-1MG : unit price : free of charge
 Chemical and Physical Properties
Product code L9001-1MG  Molecular weight 351 g/mol
Product name CLOFLUBICYNE  Physical form
CAS No. 224790-70-9 Melting point 122-126 °C
RTECS Solubility In alcohol, alcohol + water and acetone
UNIPROT Optical Activity No optical Activity
PubChem SID    
PubChem CID 5067794    
Purity 95 % (NMR).    
Toxicity(LD50) mice (i.p.): 0.1 mg/kg.
rat (p.o.): 0.2 mg/kg.
   
Chemical Name    
Storage & Reconstitution
Recommandations

Store at room temperature.

1 mg Cloflubicyne can be dissolved in 1 ml ethanol (up to 50 °C), then diluted in distilled water. Solution for experiments must contain less than 0.5 % ethanol and be stored at 0 °C.


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L9001-1MG 
Product name CLOFLUBICYNE 

- Middelton et al., J. Fluor. Chem.(1982) 20:397-418
- Fetisov et al., J. Fluor. Chem.(1991) 54:301
 Links
Product code L9001-1MG 
Product name CLOFLUBICYNE 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
Molecular formula

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