TETRODOTOXIN (citrate free)
Product ID L8503-1MG 
Name TETRODOTOXIN (citrate free) 
Molecular formula C11H17N3O8
Description

It is a highly specific Na+ channel blocker in excitable tissues.


Purified from Fugu Fish organs (Takifugu oblongus).
Biological activity

KD (cardiac myocytes in rats): 0.8 nM

10-8 M block nervous system; 10-5 M block heart muscle.

The binding to Na+ channel is reversible. ED50 = 3.7 nM.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 178.00

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5 Unité(s) 712.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8503-1MG : unit price : free of charge
 Chemical and Physical Properties
Product code L8503-1MG  Molecular weight 319.27 g/mol
Product name TETRODOTOXIN (citrate free)  Physical form White crystal powder
CAS No. 4368-28-9 Melting point It does not melt at 200 °C, darkens and turns black with increasing temperature
RTECS IO1450000 Solubility In 2% acetic or citric acid, dilute sulfuric acid
Slightly in water, dry alcohol and ether
Not in organic solvents
UNIPROT Optical Activity At 25 deg C/D: -8.64 deg (c= 8.55 in dilute acetic acid)
PubChem SID    
PubChem CID 16759596    
Purity > 99 % (HPLC), + IR, NMR    
Toxicity(LD50) IVN-MUS LD50: 7.3 µg/kg
IPR-MUS LD50: 8 - 10 µg/kg
SCU-MUS LD50: 11.5 µg/kg
ORL-MUS LD50: 334 µg/kg
ICE-MUS LD50: 600 ng/kg
ORL-RBT LD50: 7.5 µg/kg
IPR-FRG LD50: 14 µg/kg
   
Chemical Name Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d] pyrimidine-4,7,10,11,12-pentol    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C. Solid and solutions can be kept in deep freeze for a long time without any change in their activity.

Solution for use: reconstitute in citrate or acetate buffer, pH 4.8-4.9


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

Highly toxic

 
 Bibliographic References
Product code L8503-1MG 
Product name TETRODOTOXIN (citrate free) 

- Abraham et al. "Antiarrhythmic properties of tetrodotoxin against occlusion-induced arrhythmias in the rat: a novel approach to the study of the antiarrhythmic effects of ventricular sodium channel blockade." J. Pharmacol. Exp. Ther. (1989). 251(3):1166
- Lombet et al. "A cardiac tetrodotoxin binding component: biochemical identification, characterization and properties." Biochemistry (1981). 20:1279-1285
 Links
Product code L8503-1MG 
Product name TETRODOTOXIN (citrate free) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
Molecular formula

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