ARTEMETHER
Product ID L6104 
Name ARTEMETHER 
Molecular formula C16H26O5
Description

It has highly effective action against the blood schizonts of both malarial parasites P. falciparum and P. Vivax. Artemether has been shown to have significant anticancer and antitumor activities. Artemether has analgesic and antipyretic effects on the body by relieving pain and reducing fever.


Sesquiterpenoid derivative of Artemisinin, originally isolated from Artemisia annua
Biological activity

The generally accepted mechanism of action of peroxide antimalarials involves interaction of the peroxide-containing drug with heme, a hemoglobin degradation byproduct, derived from proteolysis of hemoglobin. This interaction is believed to result in the formation of a range of potentially toxic oxygen and carbon-centered radicals.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
50 mg 111.00

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250 mg 444.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L6104 : unit price : free of charge
 Chemical and Physical Properties
Product code L6104  Molecular weight 298.37 g/mol
Product name ARTEMETHER  Physical form Powder
CAS No. 71963-77-4 Melting point 89 ºC
RTECS KD4165000 Solubility DMSO: 20 mg/mL
Not in water
UNIPROT Optical Activity [?]D +155 -175° (c = 0.5 in methanol)
PubChem SID    
PubChem CID 68911    
Purity ≥ 99%    
Toxicity(LD50) Mice (i.m.): 263 mg/kg, (p.o.): 1 g/kg, (s.c.): 390 mg/kg    
Chemical Name 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR)-, (+)-    
Storage & Reconstitution
Recommandations
 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L6104 
Product name ARTEMETHER 

- Haynes RK, Vonwiller SC. Extraction of artemisinin and artemisinic acid: preparation of artemether and new analogues. Trans R Soc Trop Med Hyg. 1994 Jun;88 Suppl 1:S23-6
- Makanga M, Krudsood S. The clinical efficacy of artemether/lumefantrine (Coartem). Malar J. 2009 Oct 12;8 Suppl 1:S5. doi: 10.1186/1475-2875-8-S1-S5
- Mutabingwa TK, Adam I. Use of artemether-lumefantrine to treat malaria during pregnancy: what do we know and need to know? Expert Rev Anti Infect Ther. 2013 Feb;11(2):125-35. doi: 10.1586/eri.12.169
 Links
Product code L6104 
Product name ARTEMETHER 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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