BATRACHOTOXIN
Product ID L8301 
Name BATRACHOTOXIN 
Molecular formula C31H42N2O6
Description

The strongest sodium channel activator so far


Alkaloid with a steroid skeleton, an oxazapine ring and a dimethylpyrrole carboxylate moiety , purified from skin extract of the poison dart frog Phyllobates terribilis
Biological activity

BTX is the most active alkaloid binding at receptor site-2 on sodium channels. It activates the sodium channel even at very negative membrane potentials and keeps it open permanently by preventing channel inactivation. BTX also changes the selectivity of the channel to Na+ ions and makes it less selective, enabling larger ions to pass through the pore. EC50 (in vitro): 0.1 to 100 nanomolar. 

BTX binding induces many allosteric effects on other channel regions, and increases the binding of scorpion alpha-toxins to receptor site-3, of Brevetoxin to receptor site-5, and of pyrethroid insecticides to receptor site-7.

Research tool applicable to the study of the function of sodium channel and the effects of other toxins and of a variety of drugs, including anesthetics, analgesics, antiarrhythmics, anticonvulsants and antidepressants.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 10 µg 75.00

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1 x 20 µg 125.00

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5 x 10 µg 300.00

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1 x 100 µg 340.00

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5 x 20 µg 500.00

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5 x 100 µg 1 360.00

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1 x 500 µg 1 360.00

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1 x 1 mg 2 600.00

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5 x 500 µg 5 440.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8301 : unit price : free of charge
 Chemical and Physical Properties
Product code L8301  Molecular weight 538.67 g/mol
Product name BATRACHOTOXIN  Physical form Film
CAS No. 23509-16-2 Melting point
RTECS CR3990000 Solubility In ethanol, methanol and DMSO
UNIPROT Optical Activity [alpha]D29 300 - 260° (c = 0.23 in methanol)
PubChem SID    
PubChem CID 31958    
Purity > 90 % (HPLC, TLC, Toxicity)    
Toxicity(LD50) IPR-MUS LD50: 2 μg/kg    
Chemical Name 20-(2,4-dimethyl-1H-pyrrole-3-carboxylate)    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


dissolve in ethanol or methanol
 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8301 
Product name BATRACHOTOXIN 

- T. Tokuyama et al, J. Am Chem. Soc 91:3931 (1969)
- E. X. Albuquerque et al, Science 172:995 (1971)
- W. A. Catterall et al, J. Biol. Chem. 256:8922(1981)
- T. Tokuyama and J.W. Daly, Tetrahedron 39:41-47 (1983)
- G.B. Brown, Internat. Rev. Neurobiol. 29: 77-116 (1988)
- M. Kurosu et al., J. Am Chem.. Soc. 120: 6629 (1998)
- S. J. Wang and G. K. Wang, Cellular Signaling 15: 151 (2003)
- Batrachotoxin. RN 23509-16-2. STN Registry file (27 February 2006)
 Links
Product code L8301 
Product name BATRACHOTOXIN 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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