LUTEOLIN
Product ID L6262 
Name LUTEOLIN 
Molecular formula C15H10O6
Description

It is one of the few chemicals with a real monoamine transporter activator property. It has a potential for cancer prevention and therapy.


Flavonoid , purified from Ferula varia (Fam. Umbelliferae)
Biological activity

Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor and an interleukin 6 inhibitor affecting xylazine/ketamine-induced anesthesia in mice

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
20 mg 104.00

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100 mg 416.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L6262 : unit price : free of charge
 Chemical and Physical Properties
Product code L6262  Molecular weight 286.24 g/mol
Product name LUTEOLIN  Physical form Yellow crystalline powder
CAS No. 491-70-3 Melting point 328-330 °C
RTECS LK9275210 Solubility Soluble in:
- aqueous alkaline solutions (1.4 mg/ml),
- ethanol (~5 mg/ml),
- DMSO (7 mg/ml),
- 1eq. NaOH (5 mM),
- DMF (~20 mg/ml),
- 1:5 solution of DMF:PBS(pH7.2) (~1 mg/ml),
- water (1 mg/ml) at 25 °C,
- and methanol
UNIPROT Optical Activity
PubChem SID    
PubChem CID 5280445    
Purity > 95%    
Toxicity(LD50) IPR-MUS LD50: 180 mg/kg
ORL-RTA TDLo: 50 mg/kg
   
Chemical Name Flavone, 3',4',5,7-tetrahydroxy-    
Storage & Reconstitution
Recommandations

In a dry, cool place


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L6262 
Product name LUTEOLIN 

- Attaway J., ACS Symp.Ser. (1994), 546, (Food phytochemical for cancer prevention), 240 -248. (Eng.)
- Syrov VN et al., Dokl. AN Uz.SSR (1985), ? 3, p. 48 - 50
- Chen et al (2007) Luteolin suppresses inflammation-associated gene expression by blocking NF-?B and AP-1 activation pathway in mouse alveolar macrophage. Life Sci. 81 1602
- Ju et al (2007) A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-?B pathway and sensitization of apoptosis in lung cancer cells. Mol.Pharmacol. 71 1381
- Kim et al (2007) Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann.N.Y.Acad.Sci. 1090 597
- Kim et al (2011) Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-a-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J.Pharm.Exp.Ther. 338 1013
 Links
Product code L6262 
Product name LUTEOLIN 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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