APAMIN
Product ID L8407 
Name APAMIN 
Molecular formula C79H131N31O24S4
Description

It is a small, basic, polypeptidic toxin which blocks a class of Ca2+-activated K+ channels. It crosses the blood brain barrier and possesses a convulsant activity.


18-amino acid peptide with 2 disulfide bridges , from Apis mellifera bee venom.
Biological activity

Nanomolar concentrations block small conductance Ca2+-activated K+ channels. It induces motor hyperactivity and is a potent convulsant.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 1 mg 110.00

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5 x 1 mg 440.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8407 : unit price : free of charge
 Chemical and Physical Properties
Product code L8407  Molecular weight 2,027 g/mol
Product name APAMIN  Physical form Powder
CAS No. 24345-16-2 Melting point
RTECS CD6899900 Solubility Well in water and saline
UNIPROT P01500 Optical Activity No optical activity
PubChem SID    
PubChem CID    
Purity > 95% (HPLC)    
Toxicity(LD50) IVN-MUS LD50: 3.8 mg/kg    
Chemical Name H-Cys(1)-Asn-Cys(2)-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys(1)-Ala-Arg-Arg-Cys(2)-Gln-Gln-His-NH2    
Storage & Reconstitution
Recommandations

Store at -4 °C


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8407 
Product name APAMIN 

- Moczydlowski et al. "An emerging pharmacology of peptide toxins targeted against potassium channels." J. Membr. Biol. (1988). 105(2):95
- Bernardi et al. "Molecular properties of potassium channels." Arzneim.-Forsch./Drug Res. (1989). 39(1), 1a:159
- Merot et al. "Two types of K+ channels in the apical membrane of rabbit proximal tubule in primary culture." Biochim. Biophys. Acta (1989). 978:134
- Robertson et al. "Potassium channel modulators: Scientific applications and therapeutic promises." J. Med. Chem. (1990). 33(6):1529
 Links
Product code L8407 
Product name APAMIN 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
UNIPROT
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