L8407-1MG - APAMIN
APAMIN | Product ID | L8407-1MG |
| Name | APAMIN |
| Molecular formula | C79H131N31O24S4 |
| Description |
It is a small, basic, polypeptidic toxin which blocks a class of Ca2+-activated K+ channels. It crosses the blood brain barrier and possesses a convulsant activity. 18-amino acid peptide with 2 disulfide bridges , from Apis mellifera bee venom. |
| Biological activity | Nanomolar concentrations block small conductance Ca2+-activated K+ channels. It induces motor hyperactivity and is a potent convulsant. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 120.00 | ||
| 5 Unité(s) | 480.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8407-1MG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8407-1MG | Molecular weight | 2,027 g/mol |
| Product name | APAMIN | Physical form | Powder |
| CAS No. | 24345-16-2 | Melting point | |
| RTECS | CD6899900 | Solubility | Well in water and saline |
| UNIPROT | P01500 | Optical Activity | No optical activity |
| PubChem SID | |||
| PubChem CID | |||
| Purity | > 95% (HPLC) | ||
| Toxicity(LD50) | IVN-MUS LD50: 3.8 mg/kg | ||
| Chemical Name | H-Cys(1)-Asn-Cys(2)-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys(1)-Ala-Arg-Arg-Cys(2)-Gln-Gln-His-NH2 | ||
| Storage & Reconstitution Recommandations |
Store at -4 °C |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L8407-1MG |
| Product name | APAMIN |
- Moczydlowski et al. "An emerging pharmacology of peptide toxins targeted against potassium channels." J. Membr. Biol. (1988). 105(2):95
- Bernardi et al. "Molecular properties of potassium channels." Arzneim.-Forsch./Drug Res. (1989). 39(1), 1a:159
- Merot et al. "Two types of K+ channels in the apical membrane of rabbit proximal tubule in primary culture." Biochim. Biophys. Acta (1989). 978:134
- Robertson et al. "Potassium channel modulators: Scientific applications and therapeutic promises." J. Med. Chem. (1990). 33(6):1529
Links
| Product code | L8407-1MG |
| Product name | APAMIN |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
