IBERIOTOXIN
Product ID L8211-100UG 
Name IBERIOTOXIN 
Molecular formula C179H274N50O55S7
Description

It is a highly selective blocker of the high conductance Ca2+-activated K+ channel. Iberiotoxin appears to modulate ChTX binding by an allosteric mechanism.


37-amino acid peptide with 3 disulfide bridges. Synthetic, originally from Buthus tamulus scorpion venom.
Biological activity

As a specific blocker of Ca2+-activated K+ channels, Iberiotoxin does not affect other types of voltage-dependent K+ channels which are sensitive to inhibition by Charybdotoxin. Iberiotoxin blocks Ca2+-activated K+ channels by binding to their external mouth, and this binding is tighter and with an equilibrium dissociation constant 10-fold lower than that of Charybdotoxin.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 130.00

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5 Unité(s) 520.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8211-100UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8211-100UG  Molecular weight 4,230.85 Da
Product name IBERIOTOXIN  Physical form
CAS No. 129203-60-7 Melting point
RTECS Solubility In water and saline
UNIPROT P24663 Optical Activity
PubChem SID    
PubChem CID    
Purity 99 % (HPLC)    
Toxicity(LD50)    
Chemical Name    
Storage & Reconstitution
Recommandations
 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8211-100UG 
Product name IBERIOTOXIN 

- Galvez et al., "Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus." J. Biol. Chem. (1990) 265(19):11083-11090
- Candia et al., "Mode of action of Iberiotoxin, a potent blocker of the large conductance Ca2+-activated K+ channel." Biophys. J. (1992). 63:583-590
 Links
Product code L8211-100UG 
Product name IBERIOTOXIN 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
UNIPROT
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