Product ID L8208-100UG 
Molecular formula C171H283N55O49S8

It is a blocker of Ca2+-activated K+ channels of high conductance and some voltage-dependent K+ channels.
In human and murin beta-lymphocytes, where both K+ channels subtypes are present, Kaliotoxin is a selective voltage-dependent K+ channels blocker.

38-amino acid peptide with 3 disulfide bridges. , synthetic, originally from Androctonus mauretanicus mauretanicus scorpion venom.
Biological activity

In neurons: KTX blocks the invertebrate and mammalian sympathetic high conductance K+ channels with a Kd of 2 to 4 nM. These effects were observed on the whole-cell current as well as on the unitary channel activity.
KTX inhibits the shaker K+ current resulting from mRNA expression in Xenopus oocyte with a Kd of 2 to 5 nM.
The radiolabelled derivative 125I KTX binds to the rat brain synaptosomal membrane (Kd = 10 pM) and it is displaced by Dendrotoxin with a Kd of 8 pM.

In muscle: KTX is poorly active on skeletal high conductance K+ channels incorporated in lipid bilayers.

In lymphocytes: in human and murin b-lymphocytes, where both Ca2+-activated K+ channels and voltage-dependent K+ channels are present, KTX selectively inhibits the activity of the voltage-dependent K+ channels with a Kd of 1 to 5 nM.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 135.00

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5 Unité(s) 540.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8208-100UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8208-100UG  Molecular weight 4149.94 Da
Product name KALIOTOXIN  Physical form
CAS No. 145199-73-1 Melting point
RTECS Solubility In water and saline
UNIPROT P24662 Optical Activity
PubChem SID    
PubChem CID    
Purity > 96 % (HPLC, mass spectrometry).    
Toxicity(LD50) ICE-MUS LD50: 1.20 to 1.55 µg/kg    
Chemical Name    
Storage & Reconstitution

Stable in freeze-dried state.
In solution, keep at -20 °C.

Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use


 Bibliographic References
Product code L8208-100UG 
Product name KALIOTOXIN 

- Crest et al., "Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca2+-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom." J. Biol. Chem. (1992). 267(3):1640-1647
Product code L8208-100UG 
Product name KALIOTOXIN 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
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