SCYLLATOXIN [R7]-
Product ID L8224 
Name SCYLLATOXIN [R7]- 
Molecular formula
Description

It is an inhibitor of the binding of [125I]-apamin to rat brain synaptosomes and a specific neurotoxicity in mice.
This is a Leiurotoxin I analog whose Met7 was substituted by Arg7 (Uniprot Ref P31719)


A 31-amino acid peptide with 3 disulfide bonds , synthetic from the Leiurotoxin I, isolated from Leiurus quinquestriatus hebraeus scorpion venom
Biological activity

[R7]-Lei-OH inhibited binding of [125I]-apamin to its receptor in pharmacological experiments using rat brain synaptosomes and showed increased affinities when compared to natural toxins Lei-NH2 and Lei-OH. Experimental dose: EC50 at 0.08-0.1 nM

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 140.00

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5 x 100µg 560.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8224 : unit price : free of charge
 Chemical and Physical Properties
Product code L8224  Molecular weight 3449 Da
Product name SCYLLATOXIN [R7]-  Physical form White powder
CAS No. 116235-63-3 (Parent) Melting point
RTECS Solubility Aqueous solution
UNIPROT Optical Activity ND
PubChem SID    
PubChem CID    
Purity > 99%    
Toxicity(LD50) mice (i.c.v.): 20 ng    
Chemical Name    
Storage & Reconstitution
Recommandations

Store preferably at 4 °C


 
Savety Recommandations

Use gloves, wear mask and manipulate under hood
For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8224 
Product name SCYLLATOXIN [R7]- 

- Liebau S, Vaida B, Proepper C, Grissmer S, Storch A, Boeckers TM, Dietl P, Wittekindt OH. Formation of cellular projections in neural progenitor cells depends on SK3 channel activity. J Neurochem., 101(5):1338-1350 (2007)
- Wittekindt OH, Visan V, Tomita H, Imtiaz F, Gargus JJ, Lehmann-Horn F, Grissmer S, Morris-Rosendahl DJ. An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel. Mol Pharmacol., 65(3):788-801 (2004)
- Auguste P, Hugues M, Mourre C, Moinier D, Tartar A, Lazdunski M, Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites. Biochemistry. 31(3):648-54, (1992)
- Sabatier, J.-M., Fremont, V., Mabrouk, K., Crest, M., Darbon, H., Rochat, H., Van Rietschoten, J., Martin-Eauclaire, M.-F. Leiurotoxin I, a scorpion toxin specific for Ca2+- activated K+ channels: Structure-activity analysis using synthetic analogs. Int. J. Peptide Protein Res., 43, 486-495 (1994)
- Auguste P, Hugues M, Grav B, Gesquire JC, Maes P, Tartar A, Romey G, Schweitz H, Lazdunski M., Leiurotoxin I (scyllatoxin), a peptide ligand for Ca2(+)-activated K+ channels. Chemical synthesis, radiolabeling, and receptor characterization. J Biol Chem., 265(8):4753-9 (1990)
 Links
Product code L8224 
Product name SCYLLATOXIN [R7]- 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
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