L8224-100UG - SCYLLATOXIN [R7]-
(Syn. : Potassium channel toxin alpha-KTx 5.1, LeTx I)
(Syn. : Potassium channel toxin alpha-KTx 5.1, LeTx I)
SCYLLATOXIN [R7]- | Product ID | L8224-100UG |
| Name | SCYLLATOXIN [R7]- |
| Molecular formula | |
| Description |
It is an inhibitor of the binding of [125I]-apamin to rat brain synaptosomes and a specific neurotoxicity in mice. A 31-amino acid peptide with 3 disulfide bonds , synthetic from the Leiurotoxin I, isolated from Leiurus quinquestriatus hebraeus scorpion venom |
| Biological activity | [R7]-Lei-OH inhibited binding of [125I]-apamin to its receptor in pharmacological experiments using rat brain synaptosomes and showed increased affinities when compared to natural toxins Lei-NH2 and Lei-OH. Experimental dose: EC50 at 0.08-0.1 nM |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 152.00 | ||
| 5 Unité(s) | 608.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8224-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8224-100UG | Molecular weight | 3449 Da |
| Product name | SCYLLATOXIN [R7]- | Physical form | White powder |
| CAS No. | 116235-63-3 (Parent) | Melting point | |
| RTECS | Solubility | Aqueous solution | |
| UNIPROT | Optical Activity | ND | |
| PubChem SID | |||
| PubChem CID | |||
| Purity | > 99% | ||
| Toxicity(LD50) | mice (i.c.v.): 20 ng | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Store preferably at 4 °C
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| Savety Recommandations | Use gloves, wear mask and manipulate under hood |
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Bibliographic References
| Product code | L8224-100UG |
| Product name | SCYLLATOXIN [R7]- |
- Liebau S, Vaida B, Proepper C, Grissmer S, Storch A, Boeckers TM, Dietl P, Wittekindt OH. Formation of cellular projections in neural progenitor cells depends on SK3 channel activity. J Neurochem., 101(5):1338-1350 (2007)
- Wittekindt OH, Visan V, Tomita H, Imtiaz F, Gargus JJ, Lehmann-Horn F, Grissmer S, Morris-Rosendahl DJ. An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel. Mol Pharmacol., 65(3):788-801 (2004)
- Auguste P, Hugues M, Mourre C, Moinier D, Tartar A, Lazdunski M, Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites. Biochemistry. 31(3):648-54, (1992)
- Sabatier, J.-M., Fremont, V., Mabrouk, K., Crest, M., Darbon, H., Rochat, H., Van Rietschoten, J., Martin-Eauclaire, M.-F. Leiurotoxin I, a scorpion toxin specific for Ca2+- activated K+ channels: Structure-activity analysis using synthetic analogs. Int. J. Peptide Protein Res., 43, 486-495 (1994)
- Auguste P, Hugues M, Gravé B, Gesquière JC, Maes P, Tartar A, Romey G, Schweitz H, Lazdunski M., Leiurotoxin I (scyllatoxin), a peptide ligand for Ca2(+)-activated K+ channels. Chemical synthesis, radiolabeling, and receptor characterization. J Biol Chem., 265(8):4753-9 (1990)
Links
| Product code | L8224-100UG |
| Product name | SCYLLATOXIN [R7]- |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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