CROTAMINE CRO 2
Product ID L8118 
Name CROTAMINE CRO 2 
Molecular formula C214H326N64O54S7
Description
A 42 amino-acids peptide with 3 disulfide bridges , purified from the venom of the South American rattlesnake Crotalus durissus terrificus
Biological activity

As a potassium channel inhibitor, Crotamine selectively inhibits Kv1.1/KCNA1, Kv1.2/KCNA2 and Kv1.3/KCNA3 channels with an IC50 of 369, 386 and 287 nM respectively. Crotamine is also a fast cell-penetrating peptide (CPP) with high specificity for actively proliferating cells. To enter the cell, it interacts with the chains of heparan sulfate membrane proteoglycan (HSPG), and is then endocytosed in vesicles which are transported into the cell with the help of clathrin. Inside the cell, crotamine accumulates in lysosomal vesicles causing their disruption at high concentrations. Crotamine shows antibacterial activity against E. coli and B. subtilis, and antifungal activity against Candida spp., Trichosporon spp. and C. neoformans. It kills bacteria through membrane permeabilization.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 170.00

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5 Unité(s) 680.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8118 : unit price : free of charge
 Chemical and Physical Properties
Product code L8118  Molecular weight 4883.82 Da
Product name CROTAMINE CRO 2  Physical form White lyophilized solid
CAS No. 58740-15-1 Melting point
RTECS GP9046000 Solubility water and saline buffer
UNIPROT Q9PWF3 Optical Activity
PubChem SID    
PubChem CID 85470858    
Purity > 92 %    
Toxicity(LD50)    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8118 
Product name CROTAMINE CRO 2 

- 1. De Lucca FL., et al. (1974) Characterization of ribonucleic acids from the venom glands of Crotalus durissus terrifucus (Ophidia, Reptilia) after manual extraction of the venom. Studies on template activity and base composition. Biochem J. ;
2. Hayashi MA., et al. (2012) Crotamine: a novel cell-penetrating polypeptide nanocarrier with potential anti-cancer and biotechnological applications. Methods Mol Biol. ;
3. Kerkis A., et al. (2004) Crotamine is a novel cell-penetrating protein from the venom of rattlesnake Crotalus durissus terrificus. FASEB J. ;
4. Kerkis I., et al. (2010) Biological versatility of crotamine a cationic peptide from the venom of a South American rattlesnake. Expert Opin Investig Drugs. ;
5. Kerkis I., et al. (2014) State of the art in the studies on crotamine, a cell penetrating peptide from South American rattlesnake. Biomed Res Int. ;
6. Mancin AC., et al. (1998)  The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. ;
7. Nascimento FD (2012) The natural cell-penetrating peptide crotamine targets tumor tissue in vivo and triggers a lethal calcium-dependent pathway in cultured cells. Mol Pharm.
 Links
Product code L8118 
Product name CROTAMINE CRO 2 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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