Product ID L8121-100 UG 
Molecular formula C272H429N85O84S10
A 57 amino-acids peptide with 4 disulfide bridges , synthetic, initially isolated from the venom of the Black mamba Dendroaspis polylepis polylepis.
Biological activity

A potent and selective blocker of acid-sensing ion channels (ASIC). ASIC channels have been demonstrated to be implied in pain pathways and appear to be promising therapeutic targets. Mambalgin-1 It reversibly inhibits rat ASIC1a (IC50=3.4-55 nM), rat ASIC1a-ASIC2b (61 nM), rat ASIC1a-ASIC1b (72 nM), human ASIC1a (127-580 nM), rat ASIC1b (22.2-203 nM), rat ASIC1a-ASIC2a (152-252 nM). Mambalgin-1 has no effect on ASIC2a, ASIC3, ASIC1a+ASIC3 and ASIC1b+ASIC3 channels, as well as on TRPV1, P2X2, 5-HT3A, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin-1 differs from mambalgin-2 by one amino acid. Both have demonstrated a similar activity.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 250.00

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5 Unité(s) 1 000.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8121-100 UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8121-100 UG  Molecular weight 6554.59 Da
Product name MAMBALGIN-1  Physical form White lyophilized solid
CAS No. 1609937-15-6 Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P0DKR6 Optical Activity
PubChem SID    
PubChem CID 121513904    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution

Stable at room temperature, store preferably at 4°C

Savety Recommandations  
 Bibliographic References
Product code L8121-100 UG 
Product name MAMBALGIN-1 

- 1. Diochot S., et al. (2012) Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature. ;
2. Salinas M., et al. (2014) Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a. JBC. ;
3. Wen M., et al.  (2015) Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells. Chem Commun.
Product code L8121-100 UG 
Product name MAMBALGIN-1 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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