DISINTEGRIN OBTUSTATIN
Product ID L8127-100UG 
Name DISINTEGRIN OBTUSTATIN 
Molecular formula C184H284N52O57S8
Description
A 41 amino-acids peptide with 4 disulfide bridges , synthetic, initially isolated from the venom of the Levant blunt-nosed viper Vipera lebetina obtusa.
Biological activity

A potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin. It blocks the adhesion of alpha-1/beta-1-expressing K562 cells to immobilized collagens IV and I with IC50 of 2 and 0.5 nM, respectively. Potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half. Is 25-fold less potent than viperistatin. It does not show inhibitory activity toward alpha-2/beta-1 (ITGA2/ITGB1), alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), alpha-4/beta-1 (ITGA4/ITGB1), alpha-5/beta-1 (ITGA5/ITGB1), alpha-6/beta-1 (ITGA6/ITGB1), and alpha-9/beta-1 (ITGA9/ITGB1), alpha-4/beta-7 (ITGA4/ITGB7) integrins.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 190.00

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5 Unité(s) 760.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8127-100UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8127-100UG  Molecular weight 4393.13 Da
Product name DISINTEGRIN OBTUSTATIN  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility aqueous buffer
UNIPROT P83469 Optical Activity
PubChem SID    
PubChem CID 90488962    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8127-100UG 
Product name DISINTEGRIN OBTUSTATIN 

- 1. Brown MC, et al. (2008) Angiostatic activity of obtustatin as alpha1beta1 integrin inhibitor in experimental melanoma growth. Int J Cancer.  ;
2. Calvete JJ, et al. (2007) KTS and RTS-disintegrins: anti-angiogenic viper venom peptides specifically targeting the alpha 1 beta 1 integrin. Curr Pharm Des.  ;
3. Daidone I, et al. (2013) Structural and dynamical properties of KTS-disintegrins: A comparison between Obtustatin and Lebestatin. Biopolymers.  ;
4. Marcinkiewicz C., et al. (2003) Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo. Cancer Res.  ;
5. Moreno-Murciano M.P., et al. (2003) Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa. Protein Sci.  ;
6. Moreno-Murciano M.P., et al. (2003) NMR solution structure of the non-RGD disintegrin obtustatin. J. Mol. Biol.
 Links
Product code L8127-100UG 
Product name DISINTEGRIN OBTUSTATIN 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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