L8207-100UG - AmmTx3
(Syn. : Potassium channel toxin alpha-KTx 15.3)
(Syn. : Potassium channel toxin alpha-KTx 15.3)
AmmTx3 | Product ID | L8207-100UG |
| Name | AmmTx3 |
| Molecular formula | C158H263N51O47S6 |
| Description |
A 37 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Morrocan black thick-tailed scorpion Androctonus mauritanicus mauritanicus. |
| Biological activity | AmmTx3 binds on its target A-type potassium channel with an affinity of 66 pM in rat brain synaptosomes (Kv4 channels). AmmTx3 was found to block A-type potassium currents from cerebellum granular cells and from striatum neurons but with IC50 values of 130 nM. AmmTx3 appears to be a pore blocker of Kv4.2 and Kv4.3 and seems to require the expression of the Kv4 associated protein DPP6. It shares the same target in rat brain than AaTX1 and BmTX3, toxins with which it also shares a strong structure homology. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 110.00 | ||
| 5 Unité(s) | 440.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8207-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8207-100UG | Molecular weight | 3821.52 Da |
| Product name | AmmTx3 | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P60208 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 121513877 | ||
| Purity | > 96% (HPLC, MALDI TOF) | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
||
| Savety Recommandations | |||
Bibliographic References
| Product code | L8207-100UG |
| Product name | AmmTx3 |
- 1. Gantz SC., Bean BP. (2017) Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling. Neuron, 93(6), pp. 1375-1387.DOI: 10.1016/j.neuron.2017.02.025. PMCID:PMC5672336. ;
2. Maffie JK., et al. (2013) Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. J Physiol. ;
3. Prestipino G., et al. (2009) Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells. Toxicol Lett. ;
4. Vacher H., et al. (2002) Expanding the scorpion toxina-KTX 15 family with AmmTX3 from Androctonus mauretanicus. Eur. J. Biochem. ;
5. Vacher H., et al. (2004) Definition of the alpha-KTx15 subfamily. Toxicon.
Links
| Product code | L8207-100UG |
| Product name | AmmTx3 |
| External Links |
PubMed
|
|
Biomedical Citations From PubMed
|
|
|
Toxicology Citations From PubMed
|
|
|
PubChem CID
|
|
 UNIPROT |
