AmmTx3
Product ID L8207 
Name AmmTx3 
Molecular formula C158H263N51O47S6
Description
A 37 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Morrocan black thick-tailed scorpion Androctonus mauritanicus mauritanicus.
Biological activity

AmmTx3 binds on its target A-type potassium channel with an affinity of 66 pM in rat brain synaptosomes (Kv4 channels). AmmTx3 was found to block A-type potassium currents from cerebellum granular cells and from striatum neurons but with IC50 values of 130 nM. AmmTx3 appears to be a pore blocker of Kv4.2 and Kv4.3 and seems to require the expression of the Kv4 associated protein DPP6. It shares the same target in rat brain than AaTX1 and BmTX3, toxins with which it also shares a strong structure homology.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 110.00

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5 x 100µg 440.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8207 : unit price : free of charge
 Chemical and Physical Properties
Product code L8207  Molecular weight 3821.52 Da
Product name AmmTx3  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P60208 Optical Activity
PubChem SID    
PubChem CID 121513877    
Purity > 96% (HPLC, MALDI TOF)    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8207 
Product name AmmTx3 

- 1. Gantz SC., Bean BP. (2017) Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling. Neuron, 93(6), pp. 1375-1387.DOI: 10.1016/j.neuron.2017.02.025. PMCID:PMC5672336. ;
2. Maffie JK., et al. (2013) Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. J Physiol. ;
3. Prestipino G., et al. (2009) Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells. Toxicol Lett. ;
4. Vacher H., et al. (2002) Expanding the scorpion toxina-KTX 15 family with AmmTX3 from Androctonus mauretanicus. Eur. J. Biochem. ;
5. Vacher H., et al. (2004) Definition of the alpha-KTx15 subfamily. Toxicon.
 Links
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