L8212-100UG - TAMAPIN
TAMAPIN | Product ID | L8212-100UG |
| Name | TAMAPIN |
| Molecular formula | C146H237N44O41S6 |
| Description |
A 31 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Indian red scorpion Buthus tamulus, also known as Hottentotta tamulus ; Mesobuthus tamulus. |
| Biological activity | Tamapin binds to small conductance Ca2+-activated K+ channels (SK channels) with high affinity and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct SK channel subunits. Contrary to Apamin or Leiurotoxin-1 (Scyllatoxin), Tamapin is an excellent toxin to discriminate among SK channel subtypes because it presents different affinities for SK1 (42 nM), SK2 (24 pM) and SK3 (1.7 nM) channels. This toxin is also the most potent SK2 channel blocker characterized so far (IC50 for SK2 channels = 24 pM). |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 130.00 | ||
| 5 Unité(s) | 520.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8212-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8212-100UG | Molecular weight | 3459.00 Da |
| Product name | TAMAPIN | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P59869 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8212-100UG |
| Product name | TAMAPIN |
- 1. Blank T., et al. (2004) Small conductance Ca2+-activated K+ channels as targets of CNS drug development. Curr Drug Targets CNS Neurol Disord. ;
2. Pedarzani P et al. (2002) Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. J. Biol Chem.
Links
| Product code | L8212-100UG |
| Product name | TAMAPIN |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
