BeKm1
Product ID L8227 
Name BeKm1 
Molecular formula C174H261N51O52S6
Description
A 36 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Lesser Asian scorpion Buthus eupeus.
Biological activity

BeKm-1 toxin, a potassium channel toxin gamma-KTx 2.1, blocks human and/or rat Kv11.1/KCNH2/ERG1, Kv11.2/KCNH6/ERG2 and Kv11.3/KCNH7/ERG3 by binding to channel outer vestibule (S5P domain) with a 1:1 stoichiometry. Reported Kd and IC50 are: hERG1 (reversible, Kd=7.7 nM), IC50=3.3 nM, IC50=11.9 nM, rERG1 (reversible, Kd=19 nM), hERG2 (reversible, Kd=77 nM), rERG2 (irreversible, Kd=4.2 nM, hERG3 (reversible, Kd=11.5 nM) and rERG3 (reversible, Kd=747 nM) potassium channels. BeKm-1 toxin (at 100 nM) does not inhibit hEAG1/KCNH1, hBK/KCa1.1/KCNMA1, hSK1/KCa2.1/KCNN1, rSK2/KCa2.2/KCNN2, hIK/KCa3.1/KCNN4, KCNQ1+KCNE1, KCNQ2+KCNQ3 and KCNQ4 channels. At 50 nM it does not either inhibit Kv1.2/KCNA2, Kv1.4/KCNA4, Kv2.1/KCNB1, Kv4.3/KCND3, Kir1.1/KCNJ1.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 130.00

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5 x 100µg 520.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8227 : unit price : free of charge
 Chemical and Physical Properties
Product code L8227  Molecular weight 4091.70 Da
Product name BeKm1  Physical form White lyophilized solid
CAS No. 524962-01-4 Melting point
RTECS NA Solubility water and saline buffer
UNIPROT Q9BKB7 Optical Activity
PubChem SID    
PubChem CID 121513903    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8227 
Product name BeKm1 

- 1. Korolkova Y., et al. (2001) An ERG Channel Inhibitor from the Scorpion Buthus eupeus. JBC. ;
2. Korolkova Y., et al. (2002) New Binding Site on Common Molecular Scaffold Provides HERG Channel Specificity of Scorpion Toxin BeKm-1. JBC. ;
3. Milnes J., et al. (2003) Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin. FEBS Letters. PMID12860380 ;
4. Qu Y., et al. (2011) BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart. J Pharmacol Exp Ther. PMID 21205913 ;
5. Yi H., et al. (2007) Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res. PMID 17269718
 Links
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