L8229100UG - ADWX-1
(Syn. : ADWX-I)
(Syn. : ADWX-I)
ADWX-1 | Product ID | L8229100UG |
| Name | ADWX-1 |
| Molecular formula | C169H281N57O46S7 |
| Description |
A 37 amino-acids peptide with 3 disulfide bridges. Synthetic analog of scorpion toxin BmKTx isolated from the venom of the Chinese golden scorpion Buthus martensii venom. |
| Biological activity | ADWX-1 is an optimised synthetic analog of the scorpion peptide BmKTx. ADWX-1 is known to block voltage-gated Kv1.3channel with a high affinity (IC50 = 1.89 pM) and selectivity (340 fold greater affinity than for voltage-dependent ). ADWX-1 inhibits CD4+ CCR7- T-cell proliferation. This peptide is a valuable tool for studying the structure-function of Kv1.3 channel and auto-immunity pathways. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 140.00 | ||
| 5 Unité(s) | 560.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8229100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8229100UG | Molecular weight | 4071.90 Da |
| Product name | ADWX-1 | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | NA | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8229100UG |
| Product name | ADWX-1 |
- 1. Song Han , et al. (2008) Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease. JBC
- 2. Yin SJ (2008) Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels. Journal of proteome research
- 3. Zhi Li, et al.(2012) Selective Inhibition of CCR7? Effector Memory T Cell Activation by a Novel Peptide Targeting Kv1.3 Channel in a Rat Experimental Autoimmune Encephalomyelitis Model. JBC
Links
| Product code | L8229100UG |
| Product name | ADWX-1 |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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 UNIPROT |
