ADWX-1
Product ID L8229 
Name ADWX-1 
Molecular formula C169H281N57O46S7
Description
A 37 amino-acids peptide with 3 disulfide bridges. Synthetic analog of scorpion toxin BmKTx isolated from the venom of the Chinese golden scorpion Buthus martensii venom.
Biological activity

ADWX-1 is an optimised synthetic analog of the scorpion peptide BmKTx. ADWX-1 is known to block voltage-gated Kv1.3channel with a high affinity (IC50 = 1.89 pM) and selectivity (340 fold greater affinity than for voltage-dependent ). ADWX-1 inhibits CD4+ CCR7- T-cell proliferation. This peptide is a valuable tool for studying the structure-function of Kv1.3 channel and auto-immunity pathways.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 140.00

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5 x 100µg 560.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8229 : unit price : free of charge
 Chemical and Physical Properties
Product code L8229  Molecular weight 4071.90 Da
Product name ADWX-1  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT NA Optical Activity
PubChem SID    
PubChem CID NA    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8229 
Product name ADWX-1 

- 1. Song Han , et al. (2008) Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease. JBC
- 2. Yin SJ (2008) Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels. Journal of proteome research
- 3. Zhi Li, et al.(2012) Selective Inhibition of CCR7? Effector Memory T Cell Activation by a Novel Peptide Targeting Kv1.3 Channel in a Rat Experimental Autoimmune Encephalomyelitis Model. JBC
 Links
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