Product ID L8231-100UG 
Name HsTx1 
Molecular formula C149H246N54O46S9
A 34 amino-acids peptide with 4 disulfide bridges , synthetic, initially isolated from the venom of the Giant forest scorpion Heterometrus spinifer.
Biological activity

HsTx-1 potently blocks voltage-gated Kv1.3 channels (Kd close to 10 pM). HsTx-1 is also very active on Kv1.1 channels (IC50 around 7 nM). It is one of the most potent toxins active on Kv1.3 channel. HsTx-1 does not block Kv1.2/KCNA2 potassium channels and is inactive on apamin-sensitive SK channels.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 190.00

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5 Unité(s) 760.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8231-100UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8231-100UG  Molecular weight 3819.87 Da
Product name HsTx1  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P59867 Optical Activity
PubChem SID    
PubChem CID NA    
Purity > 99 % (HPLC, MALDI TOF)    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution

Stable at room temperature, store preferably at 4°C

Savety Recommandations  
 Bibliographic References
Product code L8231-100UG 
Product name HsTx1 

- 1. Lebrun, B., et al. (1997) A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrusspinnifer (Scorpionidae) venom. Biochem. ;
2. Rashid MH, et al. (2014) A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases. Sci Rep. ;
3. Savarin, P., et al. (1999) Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: solution structure of the potassium channel inhibitor HsTX1. Protein Sci.
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