AGITOXIN-2
Product ID L8232 
Name AGITOXIN-2 
Molecular formula C169H278N54O48S8
Description
A 38 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Palestine yellow scorpion Leiurus quinquestriatus hebraeus.
Biological activity

A potent inhibitor of the Shaker potassium channels and its mammalian homologs (Kv1.1/KCNA1, Kv1.3/KCNA3, Kv1.6/KCNA6) (Ki<1 nM for all channels). AgTx also blocks Kv1.2/KCNA2 (IC50=26.8 nM). It shows weak blocking activity on KCa3.1/KCNN4 (IC50=1152 nM).

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 130.00

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5 x 100µg 520.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8232 : unit price : free of charge
 Chemical and Physical Properties
Product code L8232  Molecular weight 4090.89 Da
Product name AGITOXIN-2  Physical form White lyophilized solid
CAS No. 168147-41-9 Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P46111 Optical Activity
PubChem SID    
PubChem CID 90489022    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8232 
Product name AGITOXIN-2 

- 1. Anangi R., et al. (2012) Recombinant Expression of Margatoxin and Agitoxin-2 in Pichia pastoris: An Efficient Method for production of KV1.3 Channel Blockers. PLoS ONE. ;
2. Garcia, M.L. et al. (1994) Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry.
 Links
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