LEIUROPEPTIDE II
Product ID L8233 
Name LEIUROPEPTIDE II 
Molecular formula C125H199N39O47S6
Description
A 29 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Palestine yellow scorpion Leiurus quinquestriatus hebraeus.
Biological activity

A specific and potent inhibitor of ClC-2/CLCN2 chloride channel. It slows ClC-2/CLCN2 activation by increasing the latency to first opening by nearly 8-fold but is unable to inhibit open channels, suggesting that this toxin inhibits channel activation gating. GaTx2 does not inhibit ClC-0, ClC-1/CLCN1, ClC-3/CLCN3, ClC-4/CLCN4, CFTR chloride channel, GABRR, calcium-activated chloride channel regulator (Cl(Ca)), Shaker, and Kv1.2/KCNA2. It shows sequence similarities with potassium channel inhibitors, but inhibits chloride channels. It is why the systematic name 'Potassium channel toxin alpha-KTx 8.3' has been moved as alternative name.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 190.00

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5 x 100µg 760.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8233 : unit price : free of charge
 Chemical and Physical Properties
Product code L8233  Molecular weight 3191.25 Da
Product name LEIUROPEPTIDE II  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P80670 Optical Activity
PubChem SID    
PubChem CID 131954575    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8233 
Product name LEIUROPEPTIDE II 

- 1. Eric E, et al. (2013) Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am J Physiol Lung Cell Mol Physiol.  ;
2. Thompson CH, et al. (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J Biol Chem.
 Links
Product code L8233 
Product name LEIUROPEPTIDE II 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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