TOXIN OD1 (alpha-)
Product ID L8234 
Name TOXIN OD1 (alpha-) 
Molecular formula C308H466N90O95S8
Description
A 65 amino-acids peptide with 4 disulfide bridges , synthetic, initially isolated from the venom of the Yellow Iranian scorpion Odontobuthus doriae.
Biological activity

Alpha-toxin OD1 affects mammalian sodium channels Nav1.7/SCN9A (EC(50)=4.5 nM), Nav1.4/SCN4A (EC(50)=9.6 nM), Nav1.6/SCN8A (EC(50)=30 nM), Nav1.5/SCN5A (only at micromolar concentrations), and insect sodium channel para/tipE (EC(50)=80 nM). In vivo, intraplantar administration of this toxin elicits pain behaviors, including licking and flinching of the hind paw, this is used as a pharmacological tool to establish a Nav1.7/SCN9A-mediated mouse model of pain. Mammalian sodium channels Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.8/SCN10A are unaffected by high concentrations.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 270.00

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5 x 100µg 1 080.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8234 : unit price : free of charge
 Chemical and Physical Properties
Product code L8234  Molecular weight 7206.20 Da
Product name TOXIN OD1 (alpha-)  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P84646 Optical Activity
PubChem SID    
PubChem CID 121513905    
Purity > 95 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations

Use gloves, wear mask and manipulate under hood.

 
 Bibliographic References
Product code L8234 
Product name TOXIN OD1 (alpha-) 

- 1. Durek T., et al. (2013) Chemical Engineering and Structural and Pharmacological Characterization of the Scorpion Toxin OD1. ACS. PIMD: 3527544 ;
- 2. Jalali A., et al. (2005) OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels. FEBS. ;
- 3. Maertens C., et al. (2006) Potent Modulation of the Voltage-Gated Sodium Channel Nav1.7 by OD1, a Toxin from the Scorpion Odonthobuthus doriae. Mol. Pharmacol.
 Links
Product code L8234 
Product name TOXIN OD1 (alpha-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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