L8425-100UG - JINGZHAOTOXIN-III
(Syn. : beta/kappa-theraphotoxin Cg1a, beta/kappa-TRTX-Cg1a, beta-theraphotoxin Cj1a, beta-TRTX-Cj1a, JZTX-III, Peptide F5-20.38)
(Syn. : beta/kappa-theraphotoxin Cg1a, beta/kappa-TRTX-Cg1a, beta-theraphotoxin Cj1a, beta-TRTX-Cj1a, JZTX-III, Peptide F5-20.38)
JINGZHAOTOXIN-III | Product ID | L8425-100UG |
| Name | JINGZHAOTOXIN-III |
| Molecular formula | C174H241N47O46S6 |
| Description |
A 36 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chinese fawn tarantula Chilobrachys jingzhao, also known as Plesiophrictus guangxiensi. |
| Biological activity | Jingzhaotoxin-III (ß-TRTX-Cj1α) selectively inhibits the activation of the voltage-dependent sodium channel Nav1.5 in heart or cancer cells with an IC50 value close to 350 nM. It is inactive on Nav1.2, Nav1.4, Nav1.6 and Nav1.7 and should therefore be considered as an interesting research tool to discriminate between sodium channel subtypes. Jingzhaotoxin-III binds onto receptor site 4 presumably located on DIIS3-S4 linker of Nav1.5 and supposedly blocks Nav1.5 through a different mechanism than ProTx-II and Huwentoxin IV. Jingzhaotoxin-III also inhibits Kv2.1 channel with an IC50 of around 700 nM. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 160.00 | ||
| 5 Unité(s) | 640.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8425-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8425-100UG | Molecular weight | 3919.53 Da |
| Product name | JINGZHAOTOXIN-III | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P62520 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 90488988 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8425-100UG |
| Product name | JINGZHAOTOXIN-III |
- 1. Mingqiang Rong, et al. (2011) Molecular basis of the tarantula toxin jingzhaotoxin-III (Beta-TRTX-Cj1 alpha) interacting with voltage sensors in sodium channel subtype Nav1.5. FASEB J. ;
2. Tao H., et al. (2013) Analysis of the interaction of tarantula toxin jingzhaotoxin-III (?-TRTX-Cj1?) with the voltage sensor of Kv2.1 uncovers the molecular basis for cross-activities on Kv2.1 and Nav1.5 channels. Biochemistry. ;
3. Yucheng Xiao, et al. (2004) Jingzhaotoxin-III, a Novel Spider Toxin Inhibiting Activation of Voltage-gated Sodium Channel in Rat Cardiac Myocytes. JBC.
Links
| Product code | L8425-100UG |
| Product name | JINGZHAOTOXIN-III |
| External Links |
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