GUANGXITOXIN-1E
Product ID L8426 
Name GUANGXITOXIN-1E 
Molecular formula C178H248N44O45S7
Description
A 36 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chinese fawn tarantula Plesiophrictus guangxiensi, also known as Chilobrachys jingzhao.
Biological activity

Guangxitoxin-1E (GxTx-1E) is a gating modifier of Kv2.1/KCNB1 (IC50=5.1 nM), Kv2.2/KCNB2 and Kv4.3/KCND3 channels (IC50=39 nM). Acts by shifting the channel activation to more depolarized potentials by stabilizing the resting conformation of the voltage sensor. It completely inhibits opening of the Kv2.1/KCNB1 channel at negative membrane voltages and dramatically shifts channel activation to positive voltages. May act by partitioning into lipid membranes and then by binding the voltage sensor paddle of the channel from a place within the membrane. It has no significant effects on Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.5/KCNA5, Kv3.2/KCNC2, Cav1.2/CACNA1C, Cav2.2/CACNA1B, Nav1.5/SCN5A, Nav1.7/SCN9A or Nav1.8/SCN10A channels.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 140.00

add to cart add to cart

5 x 100µg 560.00

add to cart add to cart

For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8426 : unit price : free of charge
 Chemical and Physical Properties
Product code L8426  Molecular weight 3948.70 Da
Product name GUANGXITOXIN-1E  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P84835 Optical Activity
PubChem SID    
PubChem CID 121513878    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8426 
Product name GUANGXITOXIN-1E 

- 1. Herrington J., (2009) Gating modifier peptides as probes of pancreatic beta-cell physiology. Toxicon.   ;
2. Herrington J., et al. (2006) Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes.  ;
3. Li XN., et al. (2013) The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. J Pharmacol Exp Ther.  ;
4. Palacio S., et al. (2017) Heterogeneity in Kv2 Channel Expression Shapes Action Potential Characteristics and Firing Patterns in CA1 versus CA2 Hippocampal Pyramidal Neurons. eNeuro. PMCID: PMC5569380. DOI: 10.1523/ENEURO.0267-17.2017. ;
5. Ratliff KS., et al. (2008) An automated electrophysiology serum shift assay for K(V) channels. Assay Drug Dev Technol. ;
6. Yoshida M., et al. (2009) Regulation of voltage-gated K+ channels by glucose metabolism in pancreatic beta-cells. FEBS Lett.   ;
7. Zhuang GQ., et al. (2009) SNAP-25(1-180) enhances insulin secretion by blocking Kv2.1 channels in rat pancreatic islet beta-cells. Biochem Biophys Res Commun.
 Links
Product code L8426 
Product name GUANGXITOXIN-1E 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
click to zoom

LOGIN
Welcome, click here to   Login !




Adress:
ZA Les Auréats, 845 Avenue Pierre Brossolette
26800 PORTES lès VALENCE - FRANCE

Phone:
+33 475 419 191

Email:
latoxan[@]latoxan.com

Web link:
www.latoxan.com