Product ID L8428 
Name GrTx1 
Molecular formula C159H243N45O41S8
A 29 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chilean rose tarantula Grammostola rosea, also known as Grammostola spatulata.
Biological activity

GrTx1 potently and selectively blocks tetrodotoxin-sensivite channels. IC50 values for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 have respectively been described to be of 0.63 nM, 0.23 nM, 0.77 nM, 1.29 nM, 0.63 nM and 0.37 nM. GrTx1 does not inhibit sodium channels Nav1.5/SCN5A (IC50=22 µM) and potassium channels Kv11.2/KCNH6, Kv11.3/KCNH7, Kv1.1/KCNA1 and Kv1.4/KCNA4 (IC50>200 µM).

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 200.00

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5 x 100µg 800.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8428 : unit price : free of charge
 Chemical and Physical Properties
Product code L8428  Molecular weight 3697.49 Da
Product name GrTx1  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P85117 Optical Activity
PubChem SID    
PubChem CID NA    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution

Stable at room temperature, store preferably at 4°C

Savety Recommandations  
 Bibliographic References
Product code L8428 
Product name GrTx1 

- 1. Clement H, et al. (2007) Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels ;
2. Redaelli E., et al. (2010) Target Promiscuity and Heterogeneous Effects of Tarantula Venom Peptides Affecting Na and K Ion Channels.
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