Product ID L8429 
Name GsAF-1 
Molecular formula C160H245N47O41S7
A 29 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chilean rose tarantula Grammostola rosea, also known as Grammostola spatulata.
Biological activity

GsAF-I inhibits voltage-gated sodium channel isoforms: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with respective IC50 values of 0.4, 0.6, 1.3, 0.3, 1.2 and 0.04 µM. In addition, the toxin blocks the hERG1 isoform with an IC50 value of 4.8 µM. GsAF-I does not inhibit sodium channels Nav1.5/SCN5A, and potassium channels Kv1.1/KCNA1, Kv1.4/KCNA4, Kv11.2/KCNH6, Kv11.3/KCNH7 (IC50>200 µM).

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 160.00

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5 x 100µg 640.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8429 : unit price : free of charge
 Chemical and Physical Properties
Product code L8429  Molecular weight 3707.48 Da
Product name GsAF-1  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P61408 Optical Activity
PubChem SID    
PubChem CID NA    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution

Stable at room temperature, store preferably at 4°C

Savety Recommandations  
 Bibliographic References
Product code L8429 
Product name GsAF-1 

- 1. Elisa Redaelli, et al. (2010) Target Promiscuity and Heterogeneous Effects of Tarantula Venom Peptides Affecting Na+ and K+ Ion Channels. JBC.
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