L8429-100UG - GsAF-1
(Syn. : beta-theraphotoxin-Gr1b, beta-TRTX-Gr1b)
(Syn. : beta-theraphotoxin-Gr1b, beta-TRTX-Gr1b)
GsAF-1 | Product ID | L8429-100UG |
| Name | GsAF-1 |
| Molecular formula | C160H245N47O41S7 |
| Description |
A 29 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chilean rose tarantula Grammostola rosea, also known as Grammostola spatulata. |
| Biological activity | GsAF-I inhibits voltage-gated sodium channel isoforms: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with respective IC50 values of 0.4, 0.6, 1.3, 0.3, 1.2 and 0.04 µM. In addition, the toxin blocks the hERG1 isoform with an IC50 value of 4.8 µM. GsAF-I does not inhibit sodium channels Nav1.5/SCN5A, and potassium channels Kv1.1/KCNA1, Kv1.4/KCNA4, Kv11.2/KCNH6, Kv11.3/KCNH7 (IC50>200 µM). |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 160.00 | ||
| 5 Unité(s) | 640.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8429-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8429-100UG | Molecular weight | 3707.48 Da |
| Product name | GsAF-1 | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P61408 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8429-100UG |
| Product name | GsAF-1 |
- 1. Elisa Redaelli, et al. (2010) Target Promiscuity and Heterogeneous Effects of Tarantula Venom Peptides Affecting Na+ and K+ Ion Channels. JBC.
Links
| Product code | L8429-100UG |
| Product name | GsAF-1 |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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 UNIPROT |
