L8430-100UG - GsAF-2
(Syn. : kappa-theraphotoxin-Gr2c, kappa-TRTX-Gr2c, Mechanotoxin-alpha)
(Syn. : kappa-theraphotoxin-Gr2c, kappa-TRTX-Gr2c, Mechanotoxin-alpha)
GsAF-2 | Product ID | L8430-100UG |
| Name | GsAF-2 |
| Molecular formula | C176H261N47O45S7 |
| Description |
A 31 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chilean rose tarantula Grammostola rosea, also known as Grammostola spatulata. |
| Biological activity | GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 160.00 | ||
| 5 Unité(s) | 640.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8430-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8430-100UG | Molecular weight | 3979.78 Da |
| Product name | GsAF-2 | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P61409 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8430-100UG |
| Product name | GsAF-2 |
- 1. Elisa Redaelli, et al. (2010) Target Promiscuity and Heterogeneous Effects of Tarantula Venom Peptides Affecting Na+ and K+ Ion Channels. JBC.
Links
| Product code | L8430-100UG |
| Product name | GsAF-2 |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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 UNIPROT |
