Product ID L8432-100UG 
Molecular formula C166H257N53O50S6
A 35 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chinese black earth tiger spider Haplopelma hainanus, also known as Cyriopagopus hainanus.
Biological activity

Hainantoxin-IV (HNTX-IV) is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). Hainantoxin-IV binds to TTX-S with an IC50 value of 34 nM in adult rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by Hainantoxin-IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 130.00

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5 Unité(s) 520.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8432-100UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8432-100UG  Molecular weight 3987.6 Da
Product name HAINANTOXIN-IV  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT D2Y232 Optical Activity
PubChem SID    
PubChem CID NA    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution

Stable at room temperature, store preferably at 4°C

Savety Recommandations  
 Bibliographic References
Product code L8432-100UG 
Product name HAINANTOXIN-IV 

- 1. Li D, et al.(2004) Structure–activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers. J Biol Chem. ;
2. Liu Y, et al. (2012) A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels. J Pept Sci. ;
3. Liu Z, et al.(2003) Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana. Cell Mol Life Sci. ;
4. Wang W., et al. (2009) Determination of disulfide bridges of two spider toxins: Hainantoxin-III and Hainantoxin-IV. J Venom Anim Toxins incl Trop Dis. ;
5. Xiao Y, et al. (2003) Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV. Eur J Pharmacol.
Product code L8432-100UG 
Product name HAINANTOXIN-IV 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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