HUWENTOXIN-I
Product ID L8433-100UG 
Name HUWENTOXIN-I 
Molecular formula C161H246N48O44S6
Description
A 33 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chinese gold earth tiger spider Ornithoctonus huwena, also known as Cyriopagopus schmidti, Haplopelma schmidti, Haplopelma huwenum.
Biological activity

An inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels (TTX-S) (IC50 ~ 50 nM) and N-type voltage-sensitive calcium channels (IC50 ~ 100 nM) in mammalian DRG, hippocampus and insect's DUM neurons. It has only a very weak effect on L-type calcium channels, no effect on TTX-R channels and virtually no effect on muscle sodium channels. Huwentoxin-I showed an antinociceptive effect in rat.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 170.00

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5 Unité(s) 680.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8433-100UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8433-100UG  Molecular weight 3751.77 Da
Product name HUWENTOXIN-I  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P56676 Optical Activity
PubChem SID    
PubChem CID NA    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8433-100UG 
Product name HUWENTOXIN-I 

- 1. Chen JQ., et al. (2005) Antinociceptive effects of intrathecally administered huwentoxin-I, a selective N-type calcium channel blocker, in the formalin test in conscious rats.  ;
2. Liang, S. P., et al. (1993) Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird spider Selenocosmia huwena, Toxicon.  ;
3. Liang, S. P., et al. (2000) The presynaptic activity of huwentoxin-I, a neurotoxin from the venom of the chinese bird spider Selenocosmia huwena, Toxicon.  ;
4. Peng, K., et al. (2001) The effect of Huwentoxin-I on Ca(2+) channels in differentiated NG108-15 cells, a patch-clamp study, Toxicon.  ;
5. Wang M, et al. (2012) The effects of huwentoxin-I on the voltage-gated sodium channels of rat hippocampal and cockroach dorsal unpaired median neurons. Peptides.  ;
6. Wang M, et al. (2007) The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons. Biochem Biophys Res Commun.  ;
7. Wang YR, et al. (2007) Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus of rat with global cerebral ischemia. Toxicon.  ;
8. Wen Tao Z, et al. (2011) The antinociceptive efficacy of HWTX-I epidurally administered in rheumatoid arthritis rats. Int J Sports Med. PMID: 22052031 ;
9. Zhou, P. A., et al. (1997) Blockade of neuromuscular transmission by huwentoxin-I, purified from the venom of the Chinese bird spider Selenocosmia huwena, Toxicon. PMID: 9028007
 Links
Product code L8433-100UG 
Product name HUWENTOXIN-I 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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