L8438-100UG - PHRIXOTOXIN-2
(Syn. : PaTx2, kappa-theraphotoxin-Ps1b, kappa-TRTX-Ps1b)
(Syn. : PaTx2, kappa-theraphotoxin-Ps1b, kappa-TRTX-Ps1b)
PHRIXOTOXIN-2 | Product ID | L8438-100UG |
| Name | PHRIXOTOXIN-2 |
| Molecular formula | C169H259N49O43S8 |
| Description |
A 31 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chilean copper tarantula Phrixotrichus auratus, also known as Paraphysa scrofa. |
| Biological activity | Phrixotoxin-2 specifically blocks recombinant Kv4.2 and Kv4.3 currents with IC50 values of 34 nM and 71 nM, respectively. It does so by altering the gating properties of the channels. The inhibition of Kv4.2 and Kv4.3 currents is fully reversible upon washout. Kv4.1 is only slightly sensitive to Phrixotoxin-2 (maximal block of 20 by 300 nM). Phrixotoxin-2 does not inhibit Kv1/KCNA, Kv2/KCNB, Kv3/KCNC, and Kv11/KCNH channels. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 160.00 | ||
| 5 Unité(s) | 640.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8438-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8438-100UG | Molecular weight | 3921.71 Da |
| Product name | PHRIXOTOXIN-2 | Physical form | White lyophilized solid |
| CAS No. | 221889-63-0 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P61231 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8438-100UG |
| Product name | PHRIXOTOXIN-2 |
- 1. Barfield J.P., et al. (2005) The Effects of Putative K+ Channel Blockers on Volume Regulation of Murine Spermatozoa. Biol reprod. ;
2. Diochot S. E, et al.€ (1999) Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. British Journal of Pharmacology.
Links
| Product code | L8438-100UG |
| Product name | PHRIXOTOXIN-2 |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
