L8444-100UG - PROTOXIN-III
(Syn. : ProTx-III, mu-theraphotoxin-Tp1a, mu-TRTX-Tp1a)
(Syn. : ProTx-III, mu-theraphotoxin-Tp1a, mu-TRTX-Tp1a)
PROTOXIN-III | Product ID | L8444-100UG |
| Name | PROTOXIN-III |
| Molecular formula | C162H246N52O43S6 |
| Description |
A 33 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Peruvian green velvet tarantula Thrixopelma pruriens. |
| Biological activity | ProTx-III (µ-TRTX-Tp1a) inhibits voltage-gated sodium channels without significantly altering the voltage dependence of activation or inactivation. The toxin preferentially inhibits hNav1.7/SCN9A (IC50=2.1 nM) > hNav1.6/SCN8A > hNav1.2/SCN2A > hNav1.1/SCN1A > hNav1.3/SCN3A channels in fluorescent assays. The toxin exhibits analgesic properties by reversing spontaneous pain induced in mice by intraplantar injection with OD1 (AC P84646), a scorpion toxin that potentiates hNav1.7/SCN9A. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 130.00 | ||
| 5 Unité(s) | 520.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8444-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8444-100UG | Molecular weight | 3802.47 Da |
| Product name | PROTOXIN-III | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P0DL64 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 121513891 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8444-100UG |
| Product name | PROTOXIN-III |
- 1. Fernanda C., et al. (2015) Identification and Characterization of ProTx-III [m-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.
Links
| Product code | L8444-100UG |
| Product name | PROTOXIN-III |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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 UNIPROT |
