CONOTOXIN-MI (alpha-)
Product ID L8505 
Name CONOTOXIN-MI (alpha-) 
Molecular formula C58H88N22O17S4
Description
A 14 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Magical cone snail Conus magus.
Biological activity

α-conotoxin MI is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors (nAChR). It blocks mammalian nAChR composed of alpha-1/delta subunits with high potency and alpha-1/gamma with a low potency, allowing to distinguish between the two agonist sites as it binds 10,000-fold more tightly to the α/δ than to the α/γ site.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 500µg 90.00

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5 x 500µg 360.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8505 : unit price : free of charge
 Chemical and Physical Properties
Product code L8505  Molecular weight 1495.08 Da
Product name CONOTOXIN-MI (alpha-)  Physical form White lyophilized solid
CAS No. 88217-10-1 Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P01521 Optical Activity
PubChem SID    
PubChem CID 25081090    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8505 
Product name CONOTOXIN-MI (alpha-) 

- 1. Jacobsen, R.B., et al. (1999) Critical residues influence the affinity and selectivity of alpha-conotoxin MI for nicotinic acetylcholine receptors, Biochemistry.  ;
2. Gray, W. R., et al. (1983) Conotoxin MI. Disulfide bonding and conformational states, J Biol Chem.  ;
3. Papineni RV., et al. (2001) Site-specific charge interactions of alpha-conotoxin MI with the nicotinic acetylcholine receptor. J Biol Chem.
 Links
Product code L8505 
Product name CONOTOXIN-MI (alpha-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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