CONOTOXIN GI (alpha-)
Product ID L8509 
Name CONOTOXIN GI (alpha-) 
Molecular formula C55H80N20O18S4
Description
A 13 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Geographer cone snail Conus geographus.
Biological activity

α-conotoxin GI is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors (nAChR). α-conotoxin GI allows to distinguish between the two agonist sites as it binds 10,000-fold more tightly to the α/δ than to the α/γ site excepted in Torpedo which is the reverse.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 500µg 90.00

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5 x 500µg 360.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8509 : unit price : free of charge
 Chemical and Physical Properties
Product code L8509  Molecular weight 1437.61 Da
Product name CONOTOXIN GI (alpha-)  Physical form White lyophilized solid
CAS No. 76862-65-2 Melting point
RTECS GL1500000 Solubility water and saline buffer
UNIPROT P01519 Optical Activity
PubChem SID    
PubChem CID 25084230    
Purity > 98 %    
Toxicity(LD50) IPR-MUS LD50: 12 µg/kg    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8509 
Product name CONOTOXIN GI (alpha-) 

- 1. Blount K., et al. (1992) Alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon.  ;
2. Groebe, DR., et al. (1997) Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors, Biochemistry.  ;
3. McManus OB., et al. (1985) Postsynaptic block of frog neuromuscular transmission by conotoxin GI. J Neurosci.  ;
4. McManus OB., et al. (1981) Peptides isolated from the venom of Conus geographus block neuromuscular transmission. Neurosci Lett.
 Links
Product code L8509 
Product name CONOTOXIN GI (alpha-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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