Product ID L8510-100UG 
Name CONOTOXIN GID (alpha-) 
Molecular formula C84H135N31O30S4
A 19 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Geographer cone snail Conus geographus.
Biological activity

α-conotoxin GID reversibly blocks alpha-3-beta-2/CHRNA3-CHRNB2 (IC50=3.1-5.1 nM), alpha-7/CHRNA7 (IC50=4.5-5.1 nM), and alpha-4-beta-2/CHRNA4-CHRNB2 (IC50=128.6-390 nM) nAChRs. It does not inhibit neuronal alpha-3-beta-4/CHRNA3-CHRNB4 and alpha-4-beta-4/CHRNA4-CHRNB4 nAChR, and muscle alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRND nAChR.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 170.00

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5 Unité(s) 680.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8510-100UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8510-100UG  Molecular weight 2185.45 Da
Product name CONOTOXIN GID (alpha-)  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P60274 Optical Activity
PubChem SID    
PubChem CID NA    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution

Stable at room temperature, store preferably at 4°C

Savety Recommandations  
 Bibliographic References
Product code L8510-100UG 
Product name CONOTOXIN GID (alpha-) 

- 1. Banerjee J., et al. (2014)  Design and synthesis of ?-conotoxin GID analogues as selective ?4?2 nicotinic acetylcholine receptor antagonists. Biopolymers.  ;
2. Leffler, A. E., et al. (2017). Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. PNAS, 114(38), 8100–8109. doi: 10.1073/pnas.1703952114. ;
3. Millard E., et al. (2009)  Inhibition of Neuronal Nicotinic  Acetylcholine Receptor Subtypes by  ?-Conotoxin GID and Analogues. JBC.  ;
4. Nicke A., et al. (2003)  Isolation, Structure, and Activity of GID, a Novel 4/7-Conotoxin with an Extended N-terminal Sequence. JBC. 
Product code L8510-100UG 
Product name CONOTOXIN GID (alpha-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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