CONOTOXIN IMI (alpha-)
Product ID L8515 
Name CONOTOXIN IMI (alpha-) 
Molecular formula C52H78N20O15S4
Description
A 12 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Imperial cone snail Conus imperialis.
Biological activity

α-conotoxin IMI blocks neuronal alpha-3/beta-2 (human and rat), alpha-7 (human and rat), and alpha-3/beta-4 (human) nAChRs. Acts voltage-independently. Competes with alpha-bungarotoxin for binding to the receptor. Binds to a different site than alpha-conotoxin IMII. Is highly active against the neuromuscular receptor in frog. It does not inhibit alpha-2-beta-2, alpha-4-beta-2, alpha-2-beta-4, alpha-3-beta-4, and alpha-4-beta-4 subunits. Has also no effect on muscle nAChRs alpha-1-beta-1-delta-epsilon.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 500µg 90.00

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5 x 500µg 360.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8515 : unit price : free of charge
 Chemical and Physical Properties
Product code L8515  Molecular weight 1352.92 Da
Product name CONOTOXIN IMI (alpha-)  Physical form White lyophilized solid
CAS No. 156467-85-5 Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P50983 Optical Activity
PubChem SID    
PubChem CID 133011    
Purity > 98 % (HPLC)    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8515 
Product name CONOTOXIN IMI (alpha-) 

- 1. Ellison, M., et al. (2003) Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites, J Biol Chem.  ;
2. Johnson, D. S., et al. (1995) Alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors, Mol Pharmacol.   ;
3. McIntosh, J. M., et al. (1994) A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI, J Biol Chem.  ;
4. Rogers, J. P., et al. (2000) Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist, J Mol Biol.
 Links
Product code L8515 
Product name CONOTOXIN IMI (alpha-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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