C-CONOTOXIN-PrXA
Product ID L8517 
Name C-CONOTOXIN-PrXA alpha-
Molecular formula C160H249N43O44S2
Description
A 32 amino-acids peptide with 1 disulfide bridge , synthetic, initially isolated from the venom of the Parian cone snail Conus parius.
Biological activity

α-C-Conotoxin PrXA potently antagonizes mouse muscle adult α1/β1/ε/δ nAChR subunits (IC50 = 1.8 nM) as well as fetal mouse muscle α1/β1/γ/δ nAChR subunits (IC50 = 3 nM). α-Conotoxin PrXA competes with α-bungarotoxin for binding at the α/δ and α/γ nAChR subunit interfaces (with higher affinity however for the α/δ subunit interface such as α-conotoxin GI and α-conotoxin MI).

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 130.00

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5 x 100µg 520.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8517 : unit price : free of charge
 Chemical and Physical Properties
Product code L8517  Molecular weight 3541.1 Da
Product name C-CONOTOXIN-PrXA alpha- Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P0C8S5 Optical Activity
PubChem SID    
PubChem CID NA    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8517 
Product name C-CONOTOXIN-PrXA alpha-

- 1. Jimenez EC., et al. (2007) AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry.  ;
2. Jimenez EC. (2013) Diversity of Conus peptides that target the nicotinic acetylcholine receptors. Philippine Science Letters
 Links
Product code L8517 
Product name C-CONOTOXIN-PrXA alpha-
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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