L8517-100UG - C-CONOTOXIN-PrXA
  				
  								
				
(Syn. : Alpha C-PrXA)			
			
						
				
					
					
						
							
								| Product ID | L8517-100UG | 
							
								| Name | C-CONOTOXIN-PrXA alpha- | 
							
								| Molecular formula | C160H249N43O44S2 | 
							
								| Description | A 32 amino-acids peptide with 1 disulfide bridge									
									, synthetic, initially isolated from the venom of the Parian cone snail Conus parius.
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								| Biological activity | α-C-Conotoxin PrXA potently antagonizes mouse muscle adult α1/β1/ε/δ nAChR subunits (IC50 = 1.8 nM) as well as fetal mouse muscle α1/β1/γ/δ nAChR subunits (IC50 = 3 nM). α-Conotoxin PrXA competes with α-bungarotoxin for binding at the α/δ and α/γ nAChR subunit interfaces (with higher affinity however for the α/δ subunit interface such as α-conotoxin GI and α-conotoxin MI). | 
						
					 
				 
				
				
				
				
					
					
						
|  | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8517-100UG : unit price : free of charge
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								| Product code | L8517-100UG | Molecular weight | 3541.1 Da | 
							
								| Product name | C-CONOTOXIN-PrXA alpha- | Physical form | White lyophilized solid | 
							
								| CAS No. | NA | Melting point |  | 
							
								| RTECS | NA | Solubility | water and saline buffer | 
							
								
								| UNIPROT | P0C8S5 | Optical Activity |  | 
							
								| PubChem SID |  |  |  | 
							
								| PubChem CID | NA |  |  | 
							
								| Purity | > 98 % |  |  | 
							
								| Toxicity(LD50) | No Data |  |  | 
							
								| Chemical Name |  |  |  | 
							
								| Storage & Reconstitution Recommandations
 | Stable at room temperature, store preferably at 4°C 
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								| Savety Recommandations |  |  | 
						
					 
				 
				
				
					
					
						
							
								| Product code | L8517-100UG | 
							
								| Product name | C-CONOTOXIN-PrXA alpha- | 
						
						
						
							- 1. Jimenez EC., et al. (2007) AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry.  ;
2. Jimenez EC. (2013) Diversity of Conus peptides that target the nicotinic acetylcholine receptors. Philippine Science Letters