Product ID L8518-500UG 
Name CONOTOXIN-PeIA alpha-
Molecular formula C65H98N22O21S4
A 16 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Grand cone snail Conus pergrandis.
Biological activity

This synthetic peptide potently and reversibly blocks alpha-9-alpha-10 nAChR (IC50=6.9-54.9 nM), alpha-3-beta-2 (IC50=9.7-97.5 nM) and alpha-6/alpha-3-beta-2-beta-3 (IC50=11.1-17.2 nM) . Also shows a weak inhibition of alpha-6/alpha-3-beta-4 (IC50=147 nM) and alpha-3-beta-4 (IC50=480-1500 nM). Alpha-conotoxin PeIA also inhibits N-type calcium channels (Ca2.2/CACNA1B) (IC50=1.1 nM) via the activation of the G protein-coupled GABA(B) receptor in DRG neurons. Alpha-conotoxin PeIA shows a very weak or no inhibition on muscle alpha-1-beta-1-gamma-delta, neuronal alpha-7, and neuronal alpha-4-beta-2 nAChR.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 130.00

add to cart add to cart

5 Unité(s) 520.00

add to cart add to cart

For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8518-500UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8518-500UG  Molecular weight 1651.9 Da
Product name CONOTOXIN-PeIA alpha- Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT Q1L777 Optical Activity
PubChem SID    
PubChem CID NA    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution

Stable at room temperature, store preferably at 4°C

Savety Recommandations  
 Bibliographic References
Product code L8518-500UG 
Product name CONOTOXIN-PeIA alpha-

- 1. Day N., et al. (2011) Structure and Activity of ?-Conotoxin PeIA at Nicotinic Acetylcholine Receptor Subtypes and GABAB Receptor-coupled N-type Calcium Channels. JBC.  ;
2. McIntosh M., et al. (2005) A novel ?-conotoxin, PeIA, cloned from Conus Pergrandis, discriminates between rat ?9?10 and ?7 nicotinic cholinergic receptor. JBC.
Product code L8518-500UG 
Product name CONOTOXIN-PeIA alpha-
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
click to zoom

Welcome, click here to   Login !

ZA Les Auréats, 845 Avenue Pierre Brossolette

+33 475 419 191


Web link: