CONOTOXIN PIA (alpha-)
Product ID L8519 
Name CONOTOXIN PIA (alpha-) 
Molecular formula C79H125N27O25S4
Description
A 18 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Purple cone snail Conus purpurascens.
Biological activity

α-conotoxin PIA potently and reversibly blocks nAChR alpha-6 or -3/beta-2 or -3 (IC50 =147 nm)> alpha-3/beta-2 > alpha-3/beta-4 (IC50=480-1500 nM). Does not block the muscle nor the major neuronal nAChR alpha-4/beta-2. It discriminates between nAChRs containing alpha-6 and alpha-3 subunits, being selective for alpha-6.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 500µg 140.00

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5 x 500µg 560.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8519 : unit price : free of charge
 Chemical and Physical Properties
Product code L8519  Molecular weight 1981.29 Da
Product name CONOTOXIN PIA (alpha-)  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P69658 Optical Activity
PubChem SID    
PubChem CID 76331978    
Purity > 98 % (HPLC)    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8519 
Product name CONOTOXIN PIA (alpha-) 

- 1. Dowell C., et al. (2003) -Conotoxin PIA Is Selective for ?6 Subunit-Containing Nicotinic Acetylcholine Receptors ;
2. Yang KC., et al. (2009) Mysterious ?6-containing nAChRs: function, pharmacology, and pathophysiology
 Links
Product code L8519 
Product name CONOTOXIN PIA (alpha-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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