L8519-500UG - CONOTOXIN PIA (alpha-)
(Syn. : alpha-Conotoxin PIA)
(Syn. : alpha-Conotoxin PIA)
CONOTOXIN PIA (alpha-) | Product ID | L8519-500UG |
| Name | CONOTOXIN PIA (alpha-) |
| Molecular formula | C79H125N27O25S4 |
| Description |
A 18 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Purple cone snail Conus purpurascens. |
| Biological activity | α-conotoxin PIA potently and reversibly blocks nAChR alpha-6 or -3/beta-2 or -3 (IC50 =147 nm)> alpha-3/beta-2 > alpha-3/beta-4 (IC50=480-1500 nM). Does not block the muscle nor the major neuronal nAChR alpha-4/beta-2. It discriminates between nAChRs containing alpha-6 and alpha-3 subunits, being selective for alpha-6. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 140.00 | ||
| 5 Unité(s) | 560.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8519-500UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8519-500UG | Molecular weight | 1981.29 Da |
| Product name | CONOTOXIN PIA (alpha-) | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P69658 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 76331978 | ||
| Purity | > 98 % (HPLC) | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8519-500UG |
| Product name | CONOTOXIN PIA (alpha-) |
- 1. Dowell C., et al. (2003) -Conotoxin PIA Is Selective for ?6 Subunit-Containing Nicotinic Acetylcholine Receptors ;
2. Yang KC., et al. (2009) Mysterious ?6-containing nAChRs: function, pharmacology, and pathophysiology
Links
| Product code | L8519-500UG |
| Product name | CONOTOXIN PIA (alpha-) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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 UNIPROT |
