NMB-1
Product ID L8523 
Name NMB-1  
Molecular formula C111H164N36O21S4
Description
A 19 amino-acids peptide with 2 disulfide bridges. Synthetic analog of cone snail toxin of ?-Conotoxin TIA isolated from the venom of the Tulip cone snail Conus tulipa.
Biological activity

NMB-1 (Noxious mechanosensation blocker 1) is an analogue of a peptide isolated from a marine conesnail. This 19 amino acid peptide has shown a 30 fold selectivity in inhibiting slowly adapting (SA) mechanically activated currents over rapidly adapting (RA) ones. It is an interesting tool to distinguish between RA and SA currents. NMB-1 significantly blocks SA currents at 1 µM in sensory neurons contrary to GsMTx4. Some results suggest that NMB-1 could also block mechanosensitive ion channels in cochlear hair cells at 5 µM.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 100µg 130.00

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5 x 100µg 520.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8523 : unit price : free of charge
 Chemical and Physical Properties
Product code L8523  Molecular weight 2467.03 Da
Product name NMB-1   Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT NA Optical Activity
PubChem SID    
PubChem CID NA    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8523 
Product name NMB-1  

- 1. Delmas P., et al. (2011). Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nature ;
2. Drew LJ., et al. (2007). High-Threshold Mechanosensitive Ion Channels Blocked by a Novel Conopeptide Mediate Pressure-Evoked Pain. PLoS ONE
 Links
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