Product ID L8440-100UG 
Molecular formula C200H318N62O57S6
A 40 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Trinidad chevron tarantula Psalmopoeus cambridgei.
Biological activity

Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) has been isolated from the venom of the Spider Psalmopoeus cambridgei (Trinidad chevron tarantula). PcTx1 is known to block potently (IC50 = 1 nM) and selectively the H+-gated sodium channel ASIC1a (acid-sensitive ion channel 1a). The blockage is rapid and reversible. PcTx1 can distinguish between the two ASIC1 splice variants ASIC1a and ASIC1b. PcTx1 loses its capacity to block ASIC1a as soon as this subunit is associated with another member of the family (ASIC2a or ASIC3). PcTx1 demonstrates an analgesic effect in acute and neuropathic pain models.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 98.00

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5 Unité(s) 392.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8440-100UG : unit price : free of charge
 Chemical and Physical Properties
Product code L8440-100UG  Molecular weight 4692.22 Da
Product name PSALMOTOXIN 1  Physical form White lyophilized solid
CAS No. NA Melting point
RTECS NA Solubility water and saline buffer
UNIPROT P60514 Optical Activity
PubChem SID    
PubChem CID 90489000    
Purity > 98 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution

Stable at room temperature, store preferably at 4°C

Savety Recommandations  
 Bibliographic References
Product code L8440-100UG 
Product name PSALMOTOXIN 1 

- 1. Bubien JK., et al. (2004) Cation selectivity and inhibition of malignant glioma Na+ channels by Psalmotoxin 1. Am J Physiol Cell Physiol.  ;
2. Darbon, H., et al. (2003) Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels, Protein Sci.  ;
3. Lazdunski, M., et al. (2000) Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels, J Biol Chem.  ;
4. Mazzuca M., et al. (2007) A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Nat Neurosci. ;
5. Qadri YJ., et al. (2009) Psalmotoxin-1 docking to human acid-sensing ion channel-1. JBC.  ;
6. Sherwood TW., et al. (2011) Heteromeric Acid-Sensing Ion Channels (ASICs) Composed of ASIC2b and ASIC1a Display Novel Channel Properties and Contribute to Acidosis-Induced Neuronal Death. The Journal of Neuroscience.  ;
7. Tian, Y., et al. (2017). Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3. Sci. Rep., 7, 13674. doi: 10.1038/s41598-017-13666-9.
Product code L8440-100UG 
Product name PSALMOTOXIN 1 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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