(Syn. : Ammodytoxin k2)
AMMODYTOXIN A | Product ID | L8105-1MG |
| Name | AMMODYTOXIN A |
| Molecular formula | C595H915N165O181S16 |
| Description |
A 122 amino-acids protein with 7 disulfide bridges , natural, extracted from Vipera ammodytes snake venom. |
| Biological activity | "ATxA is a snake venom phospholipase A2 (PLA2) that acts as a presynaptic neurotoxin in a triphasic way. ATxA shows an anticoagulant activity by binding with high affinity to activated coagulation factor X (F10) thus inhibiting the formation of the prothrombinase complex (FX/FV) and its activity (IC50 is 20 nM). ATxA was binds intracellular proteins such as calmodulin (CaM) (IC50 is 6 nM), 14-3-3 proteins gamma (YWHAG) and epsilon (YWHAE) (by similarity with AtxC), as well as R25 (by similarity with AtxC), a mitochondrial integral membrane protein found in cerebral cortex. ATxA oes not affect mKv1.1/KCNA1, rKv1.2/KCNA2, mKv1.3/KCNA3, hKv1.5/KCNA5 and mKv3.1/KCNC1 voltage-gated potassium channels." |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 273.00 | ||
| 5 Unité(s) | 1 092.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8105-1MG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8105-1MG | Molecular weight | 13779.3 Da |
| Product name | AMMODYTOXIN A | Physical form | White lyophilized solid |
| CAS No. | 97089-72-0 | Melting point | |
| RTECS | SZ6115585 | Solubility | well in water and saline.Purification: gel filtration on Sephadex G-100 and ion exchange chromotography on CM-cellulose. |
| UNIPROT | P00626 | Optical Activity | |
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| Purity | > 98% | ||
| Toxicity(LD50) | IVN-MUS LD50: 21 õg/kg | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable in freeze-dried state. In solution, keep at -20°C. |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8105-1MG |
| Product name | AMMODYTOXIN A |
- 1. Gubensek et al., Period. Biol. 82:444-447 (1980).
2. Ritonja et al., Biochimica et Biophysica Acta 828:306-312 (1985).
3. Thouin et al., Toxicon, 20:1051-1058 (1982)
4. Lee, C.Y., Tsai, M.C., Chen, Y.M., Ritonja, A. & Gubensek, F., Arch. Int. Pharmacodyn., 268, 313-324.
Links
| Product code | L8105-1MG |
| Product name | AMMODYTOXIN A |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
