AMMODYTOXIN A
Product ID L8105 
Name AMMODYTOXIN A 
Molecular formula C595H915N165O181S16
Description
A 122 amino-acids protein with 7 disulfide bridges , natural, extracted from Vipera ammodytes snake venom.
Biological activity

"ATxA is a snake venom phospholipase A2 (PLA2) that acts as a presynaptic neurotoxin in a triphasic way. ATxA shows an anticoagulant activity by binding with high affinity to activated coagulation factor X (F10) thus inhibiting the formation of the prothrombinase complex (FX/FV) and its activity (IC50 is 20 nM). ATxA was binds intracellular proteins such as calmodulin (CaM) (IC50 is 6 nM), 14-3-3 proteins gamma (YWHAG) and epsilon (YWHAE) (by similarity with AtxC), as well as R25 (by similarity with AtxC), a mitochondrial integral membrane protein found in cerebral cortex. ATxA oes not affect mKv1.1/KCNA1, rKv1.2/KCNA2, mKv1.3/KCNA3, hKv1.5/KCNA5 and mKv3.1/KCNC1 voltage-gated potassium channels."

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 250µg 75.00

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1 x 1mg 255.00

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5 x 250µg 300.00

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5 x 1mg 1 020.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8105 : unit price : free of charge
 Chemical and Physical Properties
Product code L8105  Molecular weight 13779.3 Da
Product name AMMODYTOXIN A  Physical form White lyophilized solid
CAS No. 97089-72-0 Melting point
RTECS SZ6115585 Solubility well in water and saline.Purification: gel filtration on Sephadex G-100 and ion exchange chromotography on CM-cellulose.
UNIPROT P00626 Optical Activity
PubChem SID    
PubChem CID    
Purity > 98%    
Toxicity(LD50) IVN-MUS LD50: 21 µg/kg    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable in freeze-dried state. In solution, keep at -20°C.


 
Savety Recommandations  
 Bibliographic References
Product code L8105 
Product name AMMODYTOXIN A 

- 1. Gubensek et al., Period. Biol. 82:444-447 (1980).
2. Ritonja et al., Biochimica et Biophysica Acta 828:306-312 (1985).
3. Thouin et al., Toxicon, 20:1051-1058 (1982)
4. Lee, C.Y., Tsai, M.C., Chen, Y.M., Ritonja, A. & Gubensek, F., Arch. Int. Pharmacodyn., 268, 313-324.
 Links
Product code L8105 
Product name AMMODYTOXIN A 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
UNIPROT
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