L8526-100UG - BgK Potassium channel toxin
(Syn. : Kappa-actitoxin-Bgr1a)
(Syn. : Kappa-actitoxin-Bgr1a)
BgK Potassium channel toxin | Product ID | L8526-100UG |
| Name | BgK Potassium channel toxin |
| Molecular formula | C177H287N59O53S6 |
| Description |
A 37 Amino-Acids peptide with 3 disulfide bonds , synthetic, originally extracted from the Red Warty sea anemon Bunodosoma granuliferum. |
| Biological activity | "Kappa-actitoxin-Bgr1a (BgK) inhibits voltage-dependent potassium channels of the Kv1 family (Kv1.1/KCNA1 (Kd=6 nM), Kv1.2/KCNA2 (Kd=15 nM), Kv1.3/KCNA3 (Kd=10 nM)). LD50 is 4.5 µg/kg by intracerebroventricular injection into mice. Symptoms observed are trembling of tail, fasciculations, salivation, paralysis and death." |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 185.00 | ||
| 5 Unité(s) | 740.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8526-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8526-100UG | Molecular weight | 4278.99 Da |
| Product name | BgK Potassium channel toxin | Physical form | White lyophilized solid |
| CAS No. | Melting point | ||
| RTECS | Solubility | water and saline buffer | |
| UNIPROT | P29186 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | |||
| Purity | |||
| Toxicity(LD50) | ICE-MUS LD50: 4.5 õg/kg | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
||
| Savety Recommandations | |||
Bibliographic References
| Product code | L8526-100UG |
| Product name | BgK Potassium channel toxin |
- "1. ""A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activity."", Aneiros A., Garcia I., Martinez J.R., Harvey A.L., Anderson A.J., Marshall D.L., Engstroem A., Hellman U., Karlsson E., Biochim. Biophys. Acta 1157:86-92(1993)
2. ""Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity."", Alessandri-Haber N., Lecoq A., Gasparini S., Grangier-Macmath G., Jacquet G., Harvey A.L., de Medeiros C., Rowan E.G., Gola M., Menez A., Crest M., J. Biol. Chem. 274:35653-35661(1999)."
Links
| Product code | L8526-100UG |
| Product name | BgK Potassium channel toxin |
| External Links |
PubMed
|
|
Biomedical Citations From PubMed
|
|
|
Toxicology Citations From PubMed
|
|
 UNIPROT |
