BUNGAROTOXIN (alpha-)
Product ID L8115 
Name BUNGAROTOXIN (alpha-) 
Molecular formula C338H539N97O105S11
Description
A 74 amino-acids polypeptide with 5 disulfide bridges , natural, purified from Bungarus multicinctus snake venom.
Biological activity

Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission. Blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4.2 µM).

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 1mg 67.00

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5 x 1mg 268.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8115 : unit price : free of charge
 Chemical and Physical Properties
Product code L8115  Molecular weight 7988.67 Da
Product name BUNGAROTOXIN (alpha-)  Physical form White lyophilized solid
CAS No. 11032-79-4 Melting point
RTECS EI6201400 Solubility well in water, saline and buffer (add saline or buffer after complete solubilization in water).
UNIPROT P60615 Optical Activity
PubChem SID    
PubChem CID 44264212    
Purity 97%. (PAGE analysis; FPLC)    
Toxicity(LD50) IPR-MUS LD50: 150 µg/kg    
Chemical Name    
Storage & Reconstitution
Recommandations

Store at + 4°C; in solution, keep at - 20 °C.


 
Savety Recommandations  
 Bibliographic References
Product code L8115 
Product name BUNGAROTOXIN (alpha-) 

- "1. Changeux et al., ""Use of a snake venom toxin to characterize the cholinergic receptor protein."" Proc. Nat. Acad. Sciences 67(3):1241-1247 (1970).
2. Bradley et al., ""Acetylcholine receptor binding characteristics of snake and cone snail venom postsynaptic neurotoxins: further studies with a non-radioactive assay."" Toxicon 31(7):825-834 (1993).
3. Lee et al., Mem. Inst. Butantan, Simp. Internac. 33:555 (1966). 4. Merck Index 11th Ed., No.1478"
 Links
Product code L8115 
Product name BUNGAROTOXIN (alpha-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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