DERMASEPTINE B2
Product ID L8302 
Name DERMASEPTINE B2 
Molecular formula C156H276N56O46S6
Description
A 33 amino-acids peptide , natural, isolated from the skin of Phyllomedusa bicolor, the giant leaf frog.
Biological activity
Dermaseptins are typically 27-34 amino acid residues in length and were the first vertebrate peptides demonstrated as having a lethal effect on the filamentous fungi implicated in severe opportunistic infections accompanying immunodeficiency syndrome and immunosuppressive drug therapy. practical: CMi de 0.3 à 50 µMol.
Adenoregulin (Dermasptine B2) enhances binding of agonists to adenosine A1 receptors, adenosine A2a receptors, alpha-2 adrenergic receptors and 5-hydroxytryptamine 1A receptors. Enhances guanyl nucleotide exchange which may result in the conversion of receptors to a high affinity state complexed with guanyl nucleotide free G-protein. Affects human behavior eliciting profound malaise, followed by listlessness and then euphoria.
Adenoregulin shows a potent antimicrobial activity against bacteria, fungi and protozoa. Lacks hemolytic activity. Probably acts by disturbing membrane functions with its amphipathic structure.
 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 500µg 675.00

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5 x 500µg 2 700.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8302 : unit price : free of charge
 Chemical and Physical Properties
Product code L8302  Molecular weight 3181.68 Da
Product name DERMASEPTINE B2  Physical form White lyophilized solid
CAS No. 149260-68-4 Melting point
RTECS Solubility Soluble in water.
UNIPROT P31107 Optical Activity
PubChem SID    
PubChem CID 16130875    
Purity 99 %    
Toxicity(LD50) No Data    
Chemical Name Dermaseptin B2, DRS-B2, Adenoregulin    
Storage & Reconstitution
Recommandations

Store preferably at -20°C. Solid and solutions can be kept in deep freeze for a long time without any change in their activity.


 
Savety Recommandations  
 Bibliographic References
Product code L8302 
Product name DERMASEPTINE B2 

- 1. Daly JW, Caceres J, Moni RW, Gusovsky F, Moos M Jr, Seamon KB, Milton K, Myers CW. Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10960-3.
2. Mor A, Amiche M, Nicolas P. Structure, synthesis, and activity of dermaseptin b, a novel vertebrate defensive peptide from frog skin: relationship with adenoregulin Biochemistry. 1994 May 31;33(21):6642-50.
3. Amiche, M., Ducancel, F., Mor, A., Boulain, J.C., Menez, A. and Nicolas, P. « Precursors of vertebrate peptide antibiotics, dermaseptin b and adenoregulin show considerable sequence identities with precursors for the opioid peptides, dermorphin, dermenkephalin and deltorphins. » J. Biol. Chem (1994) 269 N°27,17847-17852.
4. Olivier Lequin, Francine Bruston, Odile Convert, Gerard Chassaing, and Pierre Nicolas. « Helical Structure of Dermaseptin B2 in a Membrane-Mimetic Environment » Biochemistry 2003, 42, 10311-10323.
 Links
Product code L8302 
Product name DERMASEPTINE B2 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
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