LATROCRUSTATOXIN (alpha-)
Product ID L8411 
Name LATROCRUSTATOXIN (alpha-) 
Molecular formula C5783H9204N1590O1750S30
Description
A 1164 amino-acids peptide , natural, purified from Latrodectus (mactans) tredecimguttatus spider venom glands.
Biological activity

In crustaceans, α-latrocrustotoxin-Lt1a binds to neurexin-1-alpha (NRXN1), adhesion G protein-coupled receptor L1 (ADGRL1, also known as latrophilin-1), and receptor-type tyrosine-protein phosphatase S (PTPRS), and induces neurotransmitter exocytosis through two calcium-dependent mechanisms (membrane pore formation and signaling via latrophilin) and a yet to be defined calcium-independent mechanism binds with high affinity to presynaptic membranes; stimulates neurotransmitter release from nerve endings; increases intracellular Ca2+ concentration; the biological activity on nerve endings occurs at 10-10-10-9 M.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 50µg 118.00

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5 x 50µg 472.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8411 : unit price : free of charge
 Chemical and Physical Properties
Product code L8411  Molecular weight 129967.14 Da
Product name LATROCRUSTATOXIN (alpha-)  Physical form White lyophilized solid
CAS No. Melting point
RTECS Solubility Aqueous buffers, pH range 7.0-8.5.
UNIPROT Q9XZC0 Optical Activity
PubChem SID    
PubChem CID    
Purity > 97 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Can be stored at 4 °C in presence of sodium azide up to 0.5 mg/ml during one month without any loss of activity or protein aggregation; a small amount of the lyophilized product cannot be dissolved; repeating thawings and freezings causes a partial loss o


 
Savety Recommandations  
 Bibliographic References
Product code L8411 
Product name LATROCRUSTATOXIN (alpha-) 

- Regarding the physiochemical characteristics:
1. Krasnoperov et al. J. Natural Toxins 1:17-23 (1992).
2. Krasnoperov et al., Bioorgan. Khimiya 16(11):1567-1569 (1990) (Russian).
Regarding the biological activity:
1. Krasnoperov et al., Bioorgan. Khimiya 17(5):716-718 (1991) (Russian).
2. Krasnoperov et al., Bioorgan. Khimiya 17(10):1329-1334 (1991) (Russian).
3. Burmistrov et al., Biol. membrany 9:236-239 (1992) (Russian)
 Links
Product code L8411 
Product name LATROCRUSTATOXIN (alpha-) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
UNIPROT
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