Lqh alpha IT (Native)
Product ID L8221 
Name Lqh alpha IT (Native) 
Molecular formula C329H490N94O94S8
Description
A 66 amino-acids polypeptide with 4 disulfide bridges , natural, purified from Leiurus quinquestriatus hebraeus venom.
Biological activity

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Lqh αIT is an alpha-scorpion insect toxin, which prolongs the evoked action potential by an inhibition of sodium inactivation in insects and mammals. Highly toxic to insects, it also presents a toxicity to crustaceans and has a low, but measurable toxicity to mice.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 50µg 118.00

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5 x 50µg 472.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8221 : unit price : free of charge
 Chemical and Physical Properties
Product code L8221  Molecular weight 7517.42 Da
Product name Lqh alpha IT (Native)  Physical form White lyophilized solid
CAS No. Melting point
RTECS Solubility well in water and saline.
UNIPROT P17728 Optical Activity
PubChem SID    
PubChem CID    
Purity 96 %    
Toxicity(LD50) No Data    
Chemical Name    
Storage & Reconstitution
Recommandations

Stable at room temperature, store preferably at 4°C


 
Savety Recommandations  
 Bibliographic References
Product code L8221 
Product name Lqh alpha IT (Native) 

- 1. Tugarinov et al., (1997) Biochemistry 36,2414-2424.
2. Zilberberg et al., (1997) J. Biol. Chem. 272, 14810-14818.
3. Eitan et al., (1990) Biochemistry. 29:5941-5947
4. Gordon et al., (1996) J. Biol. Chem. 271:8034-8045
5. Karbat et al., (2004) J, Biol. Chem. 279, 31679-31686.
6. Gilles et al., (2000) Eur. J. Neurosci. 12, 2823-2832.
 Links
Product code L8221 
Product name Lqh alpha IT (Native) 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
UNIPROT
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