L8221-50UG - Lqh alpha IT (Native)
(Syn. : Alpha-insect toxin LqhaIT)
(Syn. : Alpha-insect toxin LqhaIT)
Lqh alpha IT (Native) | Product ID | L8221-50UG |
| Name | Lqh alpha IT (Native) |
| Molecular formula | C329H490N94O94S8 |
| Description |
A 66 amino-acids polypeptide with 4 disulfide bridges , natural, purified from Leiurus quinquestriatus hebraeus venom. |
| Biological activity | Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Lqh αIT is an alpha-scorpion insect toxin, which prolongs the evoked action potential by an inhibition of sodium inactivation in insects and mammals. Highly toxic to insects, it also presents a toxicity to crustaceans and has a low, but measurable toxicity to mice. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 128.00 | ||
| 5 Unité(s) | 512.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8221-50UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8221-50UG | Molecular weight | 7517.42 Da |
| Product name | Lqh alpha IT (Native) | Physical form | White lyophilized solid |
| CAS No. | Melting point | ||
| RTECS | Solubility | well in water and saline. | |
| UNIPROT | P17728 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | |||
| Purity | 96 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8221-50UG |
| Product name | Lqh alpha IT (Native) |
- 1. Tugarinov et al., (1997) Biochemistry 36,2414-2424.
2. Zilberberg et al., (1997) J. Biol. Chem. 272, 14810-14818.
3. Eitan et al., (1990) Biochemistry. 29:5941-5947
4. Gordon et al., (1996) J. Biol. Chem. 271:8034-8045
5. Karbat et al., (2004) J, Biol. Chem. 279, 31679-31686.
6. Gilles et al., (2000) Eur. J. Neurosci. 12, 2823-2832.
Links
| Product code | L8221-50UG |
| Product name | Lqh alpha IT (Native) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
